Cysteine from cystathionine and vice versa

Stable Identifier
R-MTU-937192
Type
Reaction [transition]
Species
Mycobacterium tuberculosis
Compartment
cytosol
ReviewStatus
5/5
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Cysteine from cystathionine and vice versa
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The pyridoxalphosphate-dependent enzyme MetB not only catalyzes destruction of cystathonine to cysteine but also the transfer of homoserine onto cysteine to yield cystathione from O-succinyl-L-homoserine. This ensures that cysteine and methionine can be interconverted when the need arises. (Wheeler et al, 2005)
Literature References
PubMed ID Title Journal Year
15576367 Functional demonstration of reverse transsulfuration in the Mycobacterium tuberculosis complex reveals that methionine is the preferred sulfur source for pathogenic Mycobacteria

Wheeler, PR, Coldham, NG, Keating, L, Gordon, SV, Wooff, EE, Parish, T, Hewinson, RG

J Biol Chem 2005
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Catalyst Activity

cystathionine gamma-lyase activity of PXLP-K208-MetB dimer [cytosol]

Physical Entity
PXLP-K208-MetB dimer [cytosol] (Mycobacterium tuberculosis)
Activity
cystathionine gamma-lyase activity (GO:0004123)
Authored
Stephan, R  (2010-08-19)
Reviewed
Warner, D  (2010-11-25)
Created
Jassal, B  (2010-08-25)
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