Reactome | acetylation of serine

acetylation of serine

Stable Identifier

R-MTU-936615

Type

Reaction [transition]

Species

Mycobacterium tuberculosis

Compartment

cytosol

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Although there is no direct evidence for CysE catalyzing the acetylation of serine, it has 58% identity with the serine acetyltransferase of Corynebacterium glutamicum and is upregulated in stress conditions (Haitani et al, 2006; Schnell et al, 2007; Mehra and Kaushal, 2009).

Literature References

PubMed ID	Title	Journal	Year
17567578	Structural insights into catalysis and inhibition of O-acetylserine sulfhydrylase from Mycobacterium tuberculosis. Crystal structures of the enzyme alpha-aminoacrylate intermediate and an enzyme-inhibitor complex Schnell, R, Oehlmann, W, Singh, M, Schneider, G	J Biol Chem	2007
19376862	Functional genomics reveals extended roles of the Mycobacterium tuberculosis stress response factor sigmaH Mehra, S, Kaushal, D	J Bacteriol	2009
16436075	Functional analysis of L-serine O-acetyltransferase from Corynebacterium glutamicum Haitani, Y, Awano, N, Yamazaki, M, Wada, M, Nakamori, S, Takagi, H	FEMS Microbiol Lett	2006

Participants

Input

Output

Participates

as an event of

Cysteine synthesis from O-acetylserine (Mycobacterium tuberculosis)

Catalyst Activity

serine O-acetyltransferase activity of CysE [cytosol]

Physical Entity

CysE [cytosol] (Mycobacterium tuberculosis)

Activity

serine O-acetyltransferase activity (GO:0009001)

Authored

Stephan, R (2010-06-24)

Reviewed

Warner, D (2010-11-25)

Created

Jassal, B (2010-08-24)

Cite Us!