Reactome | acetylation of serine

acetylation of serine

Stable Identifier

R-MTU-936615

Type

Reaction [transition]

Species

Mycobacterium tuberculosis

Compartment

cytosol

ReviewStatus

5/5

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Although there is no direct evidence for CysE catalyzing the acetylation of serine, it has 58% identity with the serine acetyltransferase of Corynebacterium glutamicum and is upregulated in stress conditions (Haitani et al, 2006; Schnell et al, 2007; Mehra and Kaushal, 2009).

Literature References

PubMed ID	Title	Journal	Year
17567578	Structural insights into catalysis and inhibition of O-acetylserine sulfhydrylase from Mycobacterium tuberculosis. Crystal structures of the enzyme alpha-aminoacrylate intermediate and an enzyme-inhibitor complex Oehlmann, W, Singh, M, Schneider, G, Schnell, R	J Biol Chem	2007
19376862	Functional genomics reveals extended roles of the Mycobacterium tuberculosis stress response factor sigmaH Mehra, S, Kaushal, D	J Bacteriol	2009
16436075	Functional analysis of L-serine O-acetyltransferase from Corynebacterium glutamicum Takagi, H, Nakamori, S, Haitani, Y, Awano, N, Yamazaki, M, Wada, M	FEMS Microbiol Lett	2006

Participants

Input

Output

Participates

as an event of

Cysteine synthesis from O-acetylserine (Mycobacterium tuberculosis)

Catalyst Activity

serine O-acetyltransferase activity of CysE [cytosol]

Physical Entity

CysE [cytosol] (Mycobacterium tuberculosis)

Activity

serine O-acetyltransferase activity (GO:0009001)

Authored

Stephan, R (2010-06-24)

Reviewed

Warner, D (2010-11-25)

Created

Jassal, B (2010-08-24)

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