desacetylmycothiol is acetylated to mycothiol using acetyl-CoA

Stable Identifier
R-MTU-879248
Type
Reaction [transition]
Species
Mycobacterium tuberculosis
Compartment
cytosol
ReviewStatus
5/5
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desacetylmycothiol is acetylated to mycothiol using acetyl-CoA
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The final step to yield mycothiol is an acetylation using acetyl-CoA. Compounds with other acyl groups can be produced spontaneously without the MshD enzyme and can have mycothiol activity. This explains low levels of mycothiol-like activity and traces of formyl- and succinyl-Cys-GlcN-Ins in MshD null mutants (Koledin et al, 2002)
Literature References
PubMed ID Title Journal Year
12375100 Identification of the mycothiol synthase gene (mshD) encoding the acetyltransferase producing mycothiol in actinomycetes

Koledin, T, Newton, GL, Fahey, RC

Arch Microbiol 2002
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Catalyst Activity

mycothiol synthase activity of MshD [cytosol]

Physical Entity
MshD [cytosol] (Mycobacterium tuberculosis)
Activity
mycothiol synthase activity (GO:0035447)
Authored
Stephan, R  (2010-06-07)
Reviewed
Warner, D  (2010-11-25)
Created
Stephan, R  (2010-06-16)
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