Mycothiol biosynthesis

Stable Identifier
R-MTU-879299
Type
Pathway
Species
Mycobacterium tuberculosis
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Biosynthesis of mycothiol starts from glucose-6-phosphate and proceeds directly to myo-inositol-1-phosphate, contrary to phosphatidylinositol synthesis. One of the following steps, the removal of the phosphate group, is catalyzed by a still unknown phosphatase. The pathway is essential in M. tuberculosis (Newton et al, 2006; Sareen et al., 2003)

Literature References
PubMed ID Title Journal Year
14594852 Mycothiol is essential for growth of Mycobacterium tuberculosis Erdman

Sareen, D, Newton, GL, Fahey, RC, Buchmeier, NA

J Bacteriol 2003
16940050 Biochemistry of the initial steps of mycothiol biosynthesis

Newton, GL, Ta, P, Bzymek, KP, Fahey, RC

J Biol Chem 2006
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