Formation of neural BAF (nBaf)

Stable Identifier
R-MMU-9934111
Type
Reaction [transition]
Species
Mus musculus
Compartment
nucleoplasm
ReviewStatus
5/5
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Formation of neural BAF (nBaf)
As neuronal progenitors differentiate and exit the mitotic cell cycle, the components of the npBAF complex alter. npBAF-specific subunits ACTL6A, SS18 and DPF2/PHF10 are replaced by neuron-specific subunits ACTL6B, SS18L1 and DPF1 or DPF3 (Lessard et al, 2007; Staahl et al, 2013; reviewed in Stahl and Crabtree, 2013; Kadoch and Crabtree, 2015; Innis and Cabot, 2020; Cenik and Shilatifard, 2021).
Literature References
PubMed ID Title Journal Year
17640523 An essential switch in subunit composition of a chromatin remodeling complex during neural development

Lessard, J, Wu, JI, Ranish, JA, Wan, M, Winslow, MM, Staahl, BT, Wu, H, Aebersold, R, Graef, IA, Crabtree, GR

Neuron 2007
24090879 Creating a neural specific chromatin landscape by npBAF and nBAF complexes

Staahl, BT, Crabtree, GR

Curr Opin Neurobiol 2013
32958894 COMPASS and SWI/SNF complexes in development and disease

Cenik, BK, Shilatifard, A

Nat Rev Genet 2021
26601204 Mammalian SWI/SNF chromatin remodeling complexes and cancer: Mechanistic insights gained from human genomics

Kadoch, C, Crabtree, GR

Sci Adv 2015
33143733 GBAF, a small BAF sub-complex with big implications: a systematic review

Innis, SM, Cabot, B

Epigenetics Chromatin 2020
23785148 Kinetic analysis of npBAF to nBAF switching reveals exchange of SS18 with CREST and integration with neural developmental pathways

Staahl, BT, Tang, J, Wu, W, Sun, A, Gitler, AD, Yoo, AS, Crabtree, GR

J Neurosci 2013
Participants
Input
Output
Orthologous Events
Formation of neural BAF (nBAF) (Homo sapiens)
Authored
Rothfels, K  (2025-01-06)
Reviewed
Dykhuizen, EC  (2025-02-21)
Created
Rothfels, K  (2025-01-06)
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