FBXL3:CUL1:SKP1:RBX1 ubiquitinylates phosphorylated CRY1,2

Stable Identifier
R-HSA-9932512
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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FBXL3:CUL1:SKP1:RBX1 ubiquitinylates phosphorylated CRY1,2
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The FBXL3:CUL1:SKP1:RBX1 SCF E3 ligase complex polyubiqutinylates unknown lysine residues in CRY1 and CRY2 (inferred from mouse homologs). Multiple lysines on CRY1 appear to be capable of being ubiquitinylated (inferred from mouse homologs). The linkage between ubiquitin residues in the polyubiquitin chains occurs at lysine-48 (K48) of the ubiquitin (Hirano et al. 2013).
Literature References
PubMed ID Title Journal Year
23452856 FBXL21 regulates oscillation of the circadian clock through ubiquitination and stabilization of cryptochromes

Hirano, A, Yumimoto, K, Tsunematsu, R, Matsumoto, M, Oyama, M, Kozuka-Hata, H, Nakagawa, T, Lanjakornsiripan, D, Nakayama, KI, Fukada, Y

Cell 2013
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Catalyst Activity

ubiquitin protein ligase activity of FBXL3:CUL1:SKP1:RBX1:p-S-CRY1,2 [nucleoplasm]

Physical Entity
FBXL3:CUL1:SKP1:RBX1:p-S-CRY1,2 [nucleoplasm] (Homo sapiens)
Activity
ubiquitin protein ligase activity (GO:0061630)
Inferred From
Fbxl3:Cul1:Skp1:Rbx1 ubiquitinylates phosphorylated Cry1,2 (Mus musculus)
Authored
May, B  (2024-12-19)
Reviewed
Sancar, A  (2025-02-14)
Albrecht, U  (2025-02-18)
Created
May, B  (2024-12-20)
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