p-S97-Bmal1:p-T451,T461-Clock,p-Npas2 and coactivators bind the Per2 gene

Stable Identifier
R-MMU-9926612
Type
Reaction [binding]
Species
Mus musculus
Compartment
nucleoplasm
ReviewStatus
5/5
General
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PNG
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p-S97-Bmal1:p-T451,T461-Clock,p-Npas2 and coactivators bind the Per2 gene
A dimer of phosphorylated Bmal1:Clock (Arntl:Clock) heterodimers binds adjacent E-boxes (EE element, E1E2 element) in the promoter of the Per2 gene (Akashi et al. 2006, Nakahata et al. 2008, Mongrain et al. 2011, Rey et al. 2011, Koike et al. 2012) and recruit the histone acetyltransferase Crebbp (Koike et al. 2012) and the histone methyltransferase Kmt2a (Mll1) (Katada and Sassone-Corsi 2010) to activate transcription. Large scale chromatin immunoprecipitation also indicates that Bmal1:Clock binds additional sites in the Per2 promoter (Rey et al. 2011, Koike et al. 2012). Npas2 can heterodimerize with Bmal1 in place of Clock, and the Bmal1:Npas2 heterodimer binds E-boxes and regulates Per2 expression (Reick et al. 2001, Yoshii et al. 2015, Landgraf et al. 2016).
Literature References
PubMed ID Title Journal Year
11441147 NPAS2: an analog of clock operative in the mammalian forebrain

Reick, M, Garcia, JA, Dudley, C, McKnight, SL

Science 2001
25526362 Changes in pH and NADPH regulate the DNA binding activity of neuronal PAS domain protein 2, a mammalian circadian transcription factor

Yoshii, K, Tajima, F, Ishijima, S, Sagami, I

Biochemistry 2015
26895328 NPAS2 Compensates for Loss of CLOCK in Peripheral Circadian Oscillators

Landgraf, D, Wang, LL, Diemer, T, Welsh, DK

PLoS Genet 2016
16280364 Molecular mechanism of cell-autonomous circadian gene expression of Period2, a crucial regulator of the mammalian circadian clock

Akashi, M, Ichise, T, Mamine, T, Takumi, T

Mol Biol Cell 2006
21113167 The histone methyltransferase MLL1 permits the oscillation of circadian gene expression

Katada, S, Sassone-Corsi, P

Nat Struct Mol Biol 2010
22039518 Sleep loss reduces the DNA-binding of BMAL1, CLOCK, and NPAS2 to specific clock genes in the mouse cerebral cortex

Mongrain, V, La Spada, F, Curie, T, Franken, P

PLoS One 2011
21364973 Genome-wide and phase-specific DNA-binding rhythms of BMAL1 control circadian output functions in mouse liver

Rey, G, Cesbron, F, Rougemont, J, Reinke, H, Brunner, M, Naef, F

PLoS Biol. 2011
18177499 A direct repeat of E-box-like elements is required for cell-autonomous circadian rhythm of clock genes

Nakahata, Y, Yoshida, M, Takano, A, Soma, H, Yamamoto, T, Yasuda, A, Nakatsu, T, Takumi, T

BMC Mol Biol 2008
22936566 Transcriptional architecture and chromatin landscape of the core circadian clock in mammals

Koike, N, Yoo, SH, Huang, HC, Kumar, V, Lee, C, Kim, TK, Takahashi, JS

Science 2012
Participants
Input
Output
Orthologous Events
p-S90-BMAL1:p-T451,T461-CLOCK,p-NPAS2 and coactivators bind the PER2 gene (Homo sapiens)
Authored
May, B  (2024-11-01)
Reviewed
Sancar, A  (2025-02-14)
Albrecht, U  (2025-02-18)
Created
May, B  (2024-11-01)
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