p-S90-BMAL1:p-T451,T461-CLOCK,p-NPAS2 and coactivators bind the PER2 gene

Stable Identifier
R-HSA-9922998
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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p-S90-BMAL1:p-T451,T461-CLOCK,p-NPAS2 and coactivators bind the PER2 gene
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A dimer of phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) heterodimers bind adjacent E-boxes (EE element, E1E2 element) in the promoter of the PER2 gene (inferred from mouse homologs) and recruit the histone acetyltransferase CREBBP (CBP) and the histone methyltransferase KMT2A (MLL1) to activate transcription (inferred from mouse homologs). Large scale chromatin immunoprecipitation also indicates that BMAL:CLOCK binds additional sites in the PER2 promoter (inferred from mouse homologs). NPAS2 can heterodimerize with BMAL1 in place of CLOCK, and the BMAL1:NPAS2 heterodimer binds E-boxes and regulates PER2 expression (inferred from mouse homologs).
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p-S97-Bmal1:p-T451,T461-Clock,p-Npas2 and coactivators bind the Per2 gene (Mus musculus)
Authored
May, B  (2024-09-21)
Reviewed
Sancar, A  (2025-02-14)
Albrecht, U  (2025-02-18)
Created
May, B  (2024-09-29)
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