Plin4 gene expression is positively regulated by Mll4,(Mll3) complex

Stable Identifier
R-MMU-9907277
Type
Reaction [omitted]
Species
Mus musculus
Compartment
nucleoplasm, lipid droplet
ReviewStatus
5/5
General
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PNG
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High
 | PPTX  | SBGN
Plin4 gene expression is positively regulated by Mll4,(Mll3) complex
Expression of the Plin4 gene is severely reduced in differentiating mouse brown preadipocytes expressing histone H3.3 K4M mutant or Kmt2c (Mll3) and Kmt2d (Mll4) with deleted SET domains (Jang et al. 2019: RNA-seq, supplementary information).
Literature References
PubMed ID Title Journal Year
30335158 H3.3K4M destabilizes enhancer H3K4 methyltransferases MLL3/MLL4 and impairs adipose tissue development

Jang, Y, Broun, A, Wang, C, Park, YK, Zhuang, L, Lee, JE, Froimchuk, E, Liu, C, Ge, K

Nucleic Acids Res 2019
Participants
Input
Output
This event is regulated
Positively by
Regulator
Mll4-ASCOM,(Mll3-ASCOM) [nucleoplasm] (Mus musculus)
Active Unit
Mll4-ASCOM,(Mll3-ASCOM) [nucleoplasm]
Orthologous Events
PLIN4 gene expression is stimulated by PPARG:RXRA:MLL4,(MLL3)-ASCOM complex (Homo sapiens)
Authored
Orlic-Milacic, M  (2024-04-05)
Reviewed
Aberin, MAE  (2025-10-31)
Wang, SP  (2025-10-31)
Created
Orlic-Milacic, M  (2024-04-05)
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