Agpat2 gene expression is stimulated by Pparg2:Rxra and Mll4,(Mll3) complex

Stable Identifier
R-MMU-9906994
Type
Reaction [omitted]
Species
Mus musculus
Compartment
nucleoplasm, endoplasmic reticulum membrane
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Agpat2 gene expression is stimulated by Pparg2:Rxra and Mll4,(Mll3) complex
Expression of the Agpat2 gene is severely reduced in differentiating mouse brown preadipocytes expressing histone H3.3 K4M mutant or Kmt2c (Mll3) and Kmt2d (Mll4) with deleted SET domains (Jang et al. 2019: RNA-seq, supplementary information). Based on a mouse model of hepatic steatosis, expression of the Agpat2 gene is directly stimulated by Pparg2 and the Mll4 complex (Kim et al. 2016).
Literature References
PubMed ID Title Journal Year
27806304 Critical Roles of the Histone Methyltransferase MLL4/KMT2D in Murine Hepatic Steatosis Directed by ABL1 and PPARĪ³2

Kim, DH, Kim, J, Kwon, JS, Sandhu, J, Tontonoz, P, Lee, SK, Lee, S, Lee, JW

Cell Rep 2016
30335158 H3.3K4M destabilizes enhancer H3K4 methyltransferases MLL3/MLL4 and impairs adipose tissue development

Jang, Y, Broun, A, Wang, C, Park, YK, Zhuang, L, Lee, JE, Froimchuk, E, Liu, C, Ge, K

Nucleic Acids Res 2019
Participants
Input
Output
This event is regulated
Positively by
Regulator
Activated Pparg:Rxra:Agpat2 gene:H3K4me1-Nucleosomes:Mll4,(Mll3)-ASCOM [nucleoplasm] (Mus musculus)
Active Unit
Mll4-ASCOM,(Mll3-ASCOM) [nucleoplasm]
Ncoas (Pparg,Rxra) [nucleoplasm]
PPARG natural ligands [nucleoplasm]
RXRA natural ligands [nucleoplasm]
Pparg2:Rxra [nucleoplasm]
Orthologous Events
AGPAT2 gene expression is stimulated by PPARG:RXRA:MLL4,(MLL3)-ASCOM complex (Homo sapiens)
Authored
Orlic-Milacic, M  (2024-04-04)
Reviewed
Khag, J  (2025-10-31)
Wang, SP  (2025-10-31)
Created
Orlic-Milacic, M  (2024-04-04)
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