Reactome | AGPAT2 gene expression is stimulated by PPARG:RXRA:MLL4,(MLL3)-ASCOM complex

AGPAT2 gene expression is stimulated by PPARG:RXRA:MLL4,(MLL3)-ASCOM complex

Stable Identifier

R-HSA-9859084

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

nucleoplasm, endoplasmic reticulum membrane

ReviewStatus

3/5

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Homo sapiens)

- Epigenetic regulation of gene expression (Homo sapiens)
  - Epigenetic regulation by WDR5-containing histone modifying complexes (Homo sapiens)
    - Epigenetic regulation of gene expression by MLL3 and MLL4 complexes (Homo sapiens)
      - Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes (Homo sapiens)
        
        MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis (Homo sapiens)
        
        AGPAT2 gene expression is stimulated by PPARG:RXRA:MLL4,(MLL3)-ASCOM complex (Homo sapiens)

General

SBML | | PDF

SVG | | PPTX | SBGN

AGPAT2 gene expression is stimulated by PPARG:RXRA:MLL4,(MLL3)-ASCOM complex

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Expression of the AGPAT2 gene, encoding 1-acyl-sn-glycerol-3-phosphate acyltransferase beta that localizes to the endoplasmic reticulum membrane and is responsible for conversion of lysophosphatidic acid (LPA) into phosphatidic acid (PA) is positively regulated by PPARG:RXRA heterodimers and KMT2C (MLL3)/KMT2D (MLL4) histone methyltransferases. Expression of AGPAT2 mRNA is increased in fat tissue of human subjects treated with PPARG agonist pioglitazone, and correlates with increased mRNA levels of other PPARG responsive genes, such as SCD (Yao-Borengasser et al. 2008). Expression of the AGPAT2 gene is severely reduced in differentiating mouse brown preadipocytes expressing histone H3.3 K4M mutant or Kmt2c (Mll3) and Kmt2d (Mll4) with deleted SET domains (Jang et al. 2019: RNA-seq, supplementary information). Based on a mouse model of hepatic steatosis, expression of the AGPAT2 gene is directly stimulated by PPARG2 and the MLL4 complex (Kim et al. 2016).

Literature References

PubMed ID	Title	Journal	Year
18697866	Stearoyl-coenzyme A desaturase 1 gene expression increases after pioglitazone treatment and is associated with peroxisomal proliferator-activated receptor-gamma responsiveness Kern, PA, Bodles, AM, Varma, V, Phanavanh, B, Rasouli, N, Unal, R, Rassouli, N, Ranganathan, G, Yao-Borengasser, A, McGehee, RE	J Clin Endocrinol Metab	2008