Phosphorylated Akt1 phosphorylates Connexin-43 (Gja1)

Stable Identifier
R-MMU-9857656
Type
Reaction [transition]
Species
Mus musculus
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Phosphorylated Akt1 phosphorylates Connexin-43 (Gja1)
Akt1 phosphorylated in response to mechanical loading directly phosphorylates Connexin43 (Cx43, Gja1) on serine-373 and integrin alpha5 (Itga5) on an unknown residue (Batra et al. 2014). Phosphorylation of the hexameric Gja1 hemichannel enhances its interaction with Itga5 and also enhances the opening of its pore, resulting in an efflux of prostaglandin E2 (PGE2) and ATP (Batra et al. 2014).
Literature References
PubMed ID Title Journal Year
24563481 Direct regulation of osteocytic connexin 43 hemichannels through AKT kinase activated by mechanical stimulation

Batra, N, Kar, R, Jiang, JX, Gu, S, Burra, S, Riquelme, MA

J Biol Chem 2014
Participants
Input
Output
Catalyst Activity

protein serine/threonine kinase activity of p-T308,S473-Akt1 [cytosol]

Physical Entity
p-T308,S473-Akt1 [cytosol] (Mus musculus)
Activity
protein serine/threonine kinase activity (GO:0004674)
Orthologous Events
p-T308,S473-AKT1 (phospho-PKB) phosphorylates GJA1 (Connexin-43) (Homo sapiens)
Authored
May, B  (2024-01-05)
Reviewed
Farach-Carson, MC  (2024-10-27)
Wu, D  (2024-10-27)
Created
May, B  (2024-01-08)
Cite Us!