p-T308,S473-AKT1 (phospho-PKB) phosphorylates GJA1 (Connexin-43)

Stable Identifier
R-HSA-9857661
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
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p-T308,S473-AKT1 (phospho-PKB) phosphorylates GJA1 (Connexin-43)
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AKT1 is phosphorylated in osteocytes in response to mechanical loading and directly phosphorylates Connexin43 (Cx43, GJA1) on serine-373 and integrin alpha5 (ITGA5) on an unknown residue (inferred from mouse homologs). Phosphorylation of the hexameric GJA1 hemichannel enhances its interaction with ITGA5 and also enhances the opening of its pore, resulting in an efflux of prostaglandin E2 (PGE2) and ATP (inferred from mouse homologs).
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Catalyst Activity

protein serine/threonine kinase activity of p-T308,S473-AKT1 [cytosol]

Physical Entity
p-T308,S473-AKT1 [cytosol] (Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
Inferred From
Phosphorylated Akt1 phosphorylates Connexin-43 (Gja1) (Mus musculus)
Authored
May, B  (2024-01-05)
Reviewed
Farach-Carson, MC  (2024-10-27)
Wu, D  (2024-10-27)
Created
May, B  (2024-01-08)
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