MiT family members dimerize

Stable Identifier
R-MMU-9857363
Type
Reaction [binding]
Species
Mus musculus
Compartment
nucleoplasm
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
MiT family members dimerize
MITF forms homo and heterodimers with MiT transcription factor family members TFE3, TFEB and TFEC as assessed by electrophoretic mobility shift assays using mouse proteins. All four family members are capable of forming heterodimers in all combinations (Hesemath et al 1994; Fisher et al, 1991; Zhao et al, 1993).
Literature References
PubMed ID Title Journal Year
1748288 TFEB has DNA-binding and oligomerization properties of a unique helix-loop-helix/leucine-zipper family

Fisher, DE, Carr, CS, Parent, LA, Sharp, PA

Genes Dev 1991
7958932 microphthalmia, a critical factor in melanocyte development, defines a discrete transcription factor family

Hemesath, TJ, Steingrìmsson, E, McGill, G, Hansen, MJ, Vaught, J, Hodgkinson, CA, Arnheiter, H, Copeland, NG, Jenkins, NA, Fisher, DE

Genes Dev 1994
8336698 TFEC, a basic helix-loop-helix protein, forms heterodimers with TFE3 and inhibits TFE3-dependent transcription activation

Zhao, GQ, Zhao, Q, Zhou, X, Mattei, MG, de Crombrugghe, B

Mol Cell Biol 1993
Participants
Input
Output
Orthologous Events
MITF dimerizes (Homo sapiens)
Authored
Rothfels, K  (2023-12-21)
Reviewed
Arnheiter, H  (2024-02-26)
de la Serna, IL  (2024-05-21)
Vu, HN  (2024-11-05)
Steingrímsson, E  (2024-11-05)
Created
Rothfels, K  (2024-01-04)
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