General
In mouse model systems of white and brown adipocyte differentiation, and hepatic steatosis, the Pparg:Rxra heterodimer was shown to bind to the following adipogenesis genes (for molecular details of cited studies, please refer to the inferred human reaction): Acsl1 (Nielsen et al. 2008), Acss3 (Kim et al. 2016), Agpat2 (Nielsen et al. 2008; Kim et al. 2016), Angptl4 (Nielsen et al. 2008), Cd36 gene (Nielsen et al. 2008; Kim et al. 2016), Cebpa gene (Nielsen et al. 2008; Jang et al. 2019), Cidec (Nielsen et al. 2008; Kim et al. 2008; Kim et al. 2016), Dgat2 gene (Nielsen et al. 2008), Elovl5 (Kim et al. 2016), Fabp4 gene (Tontonoz et al. 1994; Qi et al. 2003; Ge et al. 2008), Gpam (Kim et al. 2016), Lipe (Nielsen et al. 2008), Lpin1 (Lpn) (Nielsen et al. 2008), Lpl (Nielsen et al. 2008), Mgll (Nielsen et al. 2008), Pdk4 (Nielsen et al. 2008), Pex11a (Nielsen et al. 2008), Plin1 (Nielsen et al. 2008), Plin2 (Nielsen et al. 2008; Kim et al. 2016), Plin4 (Nielsen et al. 2008), Pnpla2 (Nielsen et al. 2008), Pparg (Nielsen et al. 2008), Scd (also known as Scd1 gene; Kim et al. 2016), Scd5 (Scd4 in mouse; Kim et al. 2016), Thrsp (Kim et al. 2016). Mouse gene Scd3, also identified as a direct steatotic target of Pparg and Mll4 in mice, is not conserved in humans.
