According to the model of PPARG:RXRA heterodimer function, the unliganded heterodimer binds to the regulatory elements of target genes (reviewed in Jeninga et al. 2009).

Based on studies in mouse model systems of white and brown adipocyte differentiation, and hepatic steatosis, the PPARG:RXRA heterodimer was shown to bind to the following adipogenesis genes:

ACSL1 gene (Nielsen et al. 2008: ChIP analysis of overlapping PPARG and RXRA binding sites in mouse white preadipocyte line 3T3 L1, shown in Figure 7)

ACSS3 gene (Kim et al. 2016: in mouse steatotic hepatocytes, both Pparg and the Mll4 complex bind to regulatory elements in the Acss3 gene locus)

ADIPOQ gene (Maeda et al. 2001: in cultured mouse 3T3-L1 white preadipocytes, PPARG agonists enhance mRNA expression and secretion of Adipoq, commonly known as adiponectin; based on a luciferase reporter assay, in which human ADIPOQ promoter was used in the reporter construct, PPARG agonists induce ADIPOQ promoter activation in 3T3-L1 cells; Combs et al. 2002: 14 day treatment of healthy human subjects with the PPARG agonist rosiglitazone increases circulating ADIPOQ protein; ADIPOQ serum protein levels are 5-fold suppressed in patients with severe insulin resistance caused by dominant-negative mutations in the PPARG gene; Iwaki et al. 2003: by EMSA, human PPARG:RXRA heterodimer directly binds to PPARE in the promoter region of the human ADIPOQ gene; the human ADIPOQ gene promoter contains a response element for the liver receptor homolog-1 - LRH1 - officially known as NR5A2 - in the vicinity of the PPARE and direct NR5A2 binding to the ADIPOQ gene promoter facilitates PPARG:RXRA-mediated induction of the ADIPOQ gene transcription)

AGPAT2 gene (Nielsen et al. 2008: ChIP analysis of overlapping PPARG and RXRA binding sites in mouse white preadipocyte line 3T3-L1; PPARG and RXRA bind to regulatory elements 10 kb upstream of the AGPAT2 gene transcription start site; Kim et al. 2016: in mouse steatotic hepatocytes, both Pparg and the Mll4 complex bind to regulatory elements in the Agpat2 gene locus)

ANGPTL4 gene (Nielsen et al. 2008: ChIP analysis of overlapping PPARG and RXRA binding sites in mouse white preadipocyte line 3T3-L1)

CD36 gene (Nielsen et al. 2008: ChIP analysis of overlapping PPARG and RXRA binding sites in mouse white preadipocyte line 3T3-L1; Kim et al. 2016: in mouse steatotic hepatocytes, both Pparg and the Mll4 complex bind to regulatory elements in the Cd36 gene locus)

CEBPA gene (Nielsen et al. 2008: ChIP analysis of overlapping PPARG and RXRA binding sites in mouse white preadipocyte line 3T3-L1; Jang et al. 2019: based on ChIP-seq analysis in mouse brown preadipocytes, PPARG binds to enhancers of the CEBPA gene)

CIDEC gene (Nielsen et al. 2008: ChIP analysis of overlapping PPARG and RXRA binding sites in mouse white preadipocyte line 3T3-L1; PPARG and RXRA associate with a region about 3 kb upstream of the CIDEC gene transcription start site; Kim et al. 2008: putative PPAREs were identified in the mouse Cidec promoter; by ChIP, EMSA, and reporter assays, mouse Pparg2 binds to the PPAREs in the promoter of the mouse Cidec gene; Kim et al. 2016: in mouse steatotic hepatocytes, both Pparg and the Mll4 complex bind to regulatory elements in the Cidec gene locus)

DGAT2 gene (Nielsen et al. 2008: ChIP analysis of overlapping PPARG and RXRA binding sites in mouse white preadipocyte line 3T3-L1, shown in Figure 7)

ELOVL5 (Kim et al. 2016: in mouse steatotic hepatocytes, both Pparg and the Mll4 complex bind to regulatory elements in the Elovl5 gene locus)

FABP4 gene (Tontonoz et al. 1994: based on a DNA mobility shift assay in HIB-1B cell line, derived from mouse brown adipocyte tumor (hibernoma), the PPARG:RXRA heterodimer binds the enhancer of the FABP4 gene; it could not be determined whether the Pparg isoform bound to Rxra was Pparg1 or Pparg2, although Pparg2 was much more abundant in HIB 1B cells; Qi et al. 2003: by ChIP, endogenous mouse Pparg - unspecified isoform - and recombinant mouse Pparg1 bind to Fabp4 gene promoter in MEFs stimulated to differentiate into adipocytes in the absence of Pparg ligands, although binding is increased in the presence of ligands; Ge et al. 2008: based on ChIP in MEFs, PPARG binds to the promoter region of the FABP4 gene)

GPAM (Kim et al. 2016: in mouse steatotic hepatocytes, both Pparg and the Mll4 complex bind to regulatory elements in the Gpam gene locus)

LIPE gene (Nielsen et al. 2008: ChIP analysis of overlapping PPARG and RXRA binding sites in mouse white preadipocyte line 3T3-L1, shown in Figure 7)

LPIN1 (LPN) gene (Nielsen et al. 2008: ChIP analysis of overlapping PPARG and RXRA binding sites in mouse white preadipocyte line 3T3-L1, shown in Figure 7)

LPL gene (Nielsen et al. 2008: ChIP analysis of overlapping PPARG and RXRA binding sites in mouse white preadipocyte line 3T3-L1)

MGLL gene (Nielsen et al. 2008: ChIP analysis of overlapping PPARG and RXRA binding sites in mouse white preadipocyte line 3T3-L1, shown in Figure 7)

PDK4 gene (Nielsen et al. 2008: ChIP analysis of overlapping PPARG and RXRA binding sites in mouse white preadipocyte line 3T3-L1)

PEX11A gene (Nielsen et al. 2008: ChIP analysis of overlapping PPARG and RXRA binding sites in mouse white preadipocyte line 3T3-L1)

PLIN1 gene (Nielsen et al. 2008: ChIP analysis of overlapping PPARG and RXRA binding sites in mouse white preadipocyte line 3T3-L1)

PLIN2 gene (Nielsen et al. 2008: ChIP analysis of overlapping PPARG and RXRA binding sites in mouse white preadipocyte line 3T3-L1; Kim et al. 2016: in mouse steatotic hepatocytes, both Pparg and the Mll4 complex bind to regulatory elements in the Plin2 gene locus)

PLIN4 gene (Nielsen et al. 2008: ChIP analysis of overlapping PPARG and RXRA binding sites in mouse white preadipocyte line 3T3-L1, shown in Figure 7)

PNPLA2 gene (Nielsen et al. 2008: ChIP analysis of overlapping PPARG and RXRA binding sites in mouse white preadipocyte line 3T3-L1)

PPARG gene (Nielsen et al. 2008: ChIP analysis of overlapping PPARG and RXRA binding sites in mouse white preadipocyte line 3T3-L1; PPARG and RXRA bind both just upstream of the promoter region of the PPARG2 isoform, and to a region ~15-25 kb downstream from the PPARG locus)
SCD gene (also known as SCD1 gene; Kim et al. 2016: in mouse steatotic hepatocytes, both Pparg and the Mll4 complex bind to regulatory elements in the Scd gene locus)

SCD5 (also known as SCD2 or SCD4; Scd4 in mouse; Kim et al. 2016: in mouse steatotic hepatocytes, both Pparg and the Mll4 complex bind to regulatory elements in the Scd4 gene locus)

THRSP (Kim et al. 2016: in mouse steatotic hepatocytes, both Pparg and the Mll4 complex bind to regulatory elements in the Thrsp gene locus).

Mouse gene Scd3, also identified as a direct steatotic target of Pparg and Mll4 in mice, is not conserved in humans.