Phosphorylation of ITAMs of Ig-alpha (Cd79a) and Ig-beta (Cd79b)

Stable Identifier
R-MMU-983702
Type
Reaction [omitted]
Species
Mus musculus
Compartment
plasma membrane, cytosol
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Phosphorylation of ITAMs of Ig-alpha (Cd79a) and Ig-beta (Cd79b)
The immunoreceptor tyrosine activation motifs (ITAMs) of Cd79a and Cd79b are phosphorylated by Lyn, Fyn, and Blk kinases in response to antigen binding (Burkhardt et al. 1991, Gold et al. 1991, Yamanashi et al. 1991, Campbell and Sefton 1992, Lin and Justement 1992, Kim et al. 1993, Johnson et al. 1995, Flaswinkel and Reth 1994, Saouaf et al. 1994, Saouaf et al. 1995, Yao et al. 1995, Rolli et al. 2002). Lyn, Fyn, and Blk may phosphorylate one tyrosine within the ITAMs while the other tyrosine is phosphorylated by Syk (Yamanashi et al. 1991, Flaswinkel and Reth 1994, Rolli et al. 2002).
Literature References
PubMed ID Title Journal Year
1569953 Association between B-lymphocyte membrane immunoglobulin and multiple members of the Src family of protein tyrosine kinases

Campbell, MA, Sefton, BM

Mol Cell Biol 1992
1506682 The MB-1/B29 heterodimer couples the B cell antigen receptor to multiple src family protein tyrosine kinases

Lin, J, Justement, LB

J Immunol 1992
7608543 Immunoreceptor tyrosine-based activation motif is required to signal pathways of receptor-mediated growth arrest and apoptosis in murine B lymphoma cells

Yao, XR, Flaswinkel, H, Reth, M, Scott, DW

J Immunol 1995
7594458 Phosphorylated immunoreceptor signaling motifs (ITAMs) exhibit unique abilities to bind and activate Lyn and Syk tyrosine kinases

Johnson, SA, Pleiman, CM, Pao, L, Schneringer, J, Hippen, K, Cambier, JC

J Immunol 1995
7592958 Reconstitution of the B cell antigen receptor signaling components in COS cells

Saouaf, SJ, Kut, SA, Fargnoli, J, Rowley, RB, Bolen, JB, Mahajan, S

J Biol Chem 1995
1702903 Association of B cell antigen receptor with protein tyrosine kinase Lyn

Yamanashi, Y, Kakiuchi, T, Mizuguchi, J, Yamamoto, T, Toyoshima, K

Science 1991
8306975 Dual role of the tyrosine activation motif of the Ig-alpha protein during signal transduction via the B cell antigen receptor

Flaswinkel, H, Reth, M

EMBO J 1994
7681402 Differential signaling through the Ig-alpha and Ig-beta components of the B cell antigen receptor

Kim, KM, Alber, G, Weiser, P, Reth, M

Eur J Immunol 1993
23593269 Fyn kinase is required for optimal humoral responses

Chaimowitz, NS, Falanga, YT, Ryan, JJ, Conrad, DH

PLoS ONE 2013
1707541 Tyrosine phosphorylation of components of the B-cell antigen receptors following receptor crosslinking

Gold, MR, Matsuuchi, L, Kelly, RB, DeFranco, AL

Proc Natl Acad Sci U S A 1991
7524079 Temporal differences in the activation of three classes of non-transmembrane protein tyrosine kinases following B-cell antigen receptor surface engagement

Saouaf, SJ, Mahajan, S, Rowley, RB, Kut, SA, Fargnoli, J, Burkhardt, AL, Tsukada, S, Witte, ON, Bolen, JB

Proc Natl Acad Sci U S A 1994
1714601 Anti-immunoglobulin stimulation of B lymphocytes activates src-related protein-tyrosine kinases

Burkhardt, AL, Brunswick, M, Bolen, JB, Mond, JJ

Proc Natl Acad Sci U S A 1991
Participants
Input
Output
Catalyst Activity

protein tyrosine kinase activity of Lyn [cytosol]

Physical Entity
Lyn [cytosol] (Mus musculus)
Activity
protein tyrosine kinase activity (GO:0004713)

protein tyrosine kinase activity of Fyn [cytosol]

Physical Entity
Fyn [cytosol] (Mus musculus)
Activity
protein tyrosine kinase activity (GO:0004713)

protein tyrosine kinase activity of Tyrosine-protein kinase Blk [cytosol]

Physical Entity
Tyrosine-protein kinase Blk [cytosol] (Mus musculus)
Activity
protein tyrosine kinase activity (GO:0004713)
Orthologous Events
LYN, FYN, BLK phosphorylate ITAMs of Ig-alpha (CD79A) and Ig-beta (CD79B) (Homo sapiens)
Authored
May, B  (2010-09-28)
Reviewed
Wienands, J  (2012-02-12)
Created
May, B  (2010-11-02)
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