Expression of Pax6 in anterior neural plate

Stable Identifier
R-MMU-9832816
Type
Reaction [omitted]
Species
Mus musculus
Compartment
nucleoplasm
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Expression of Pax6 in anterior neural plate
During gastrulation at embryonic day 7.5, Pax6 is strongly expressed in the anterior neural plate and more weakly expressed in the posterior neural plate (Iwafuchi-Doi et al. 2012). During differentiation of embryonic stem cells to neural tissue, Pax6 is directly activated by Pou3f1 (Zhu et al. 2014) and Znf521 (Zfp521) (Kamiya et al. 2011).
Literature References
PubMed ID Title Journal Year
24929964 The transcription factor Pou3f1 promotes neural fate commitment via activation of neural lineage genes and inhibition of external signaling pathways

Jing, N, Chen, J, Song, L, Sun, N, Sheng, N, Zhang, T, Peng, G, Zhu, Q, Li, J, Qiao, Y, Tang, W, Qian, C, Han, JD, Tang, K

Elife 2014
22992956 Transcriptional regulatory networks in epiblast cells and during anterior neural plate development as modeled in epiblast stem cells

Aruga, J, Matsuda, K, Kondoh, H, Niwa, H, Tesar, PJ, Iwafuchi-Doi, M, Murakami, K, Matsuo, I

Development 2012
21326203 Intrinsic transition of embryonic stem-cell differentiation into neural progenitors

Sasai, N, Kiyonari, H, Ohgushi, M, Kawada, M, Yakura, R, Nishikawa, S, Jakt, LM, Sasai, Y, Kamiya, D, Nakao, K, Watanabe, K, Inomata, H, Banno, S

Nature 2011
Participants
Input
Output
This event is regulated
Positively by
Regulator
Pou3f1:Znf521:Pax6 gene [nucleoplasm] (Mus musculus)
Active Unit
Znf521 [nucleoplasm]
Pou3f1 [nucleoplasm]
Orthologous Events
Expression of PAX6 in anterior neural plate (Homo sapiens)
Authored
May, B  (2023-04-09)
Reviewed
Kondoh, H  (2023-07-12)
Created
May, B  (2023-04-09)
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