Expression of Wnt4 during nephron development

Stable Identifier
R-MMU-9832372
Type
Reaction [omitted]
Species
Mus musculus
Compartment
nucleoplasm
ReviewStatus
3/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Expression of Wnt4 during nephron development
Wnt9b secreted from the ureteric bud induces expression of Wnt4 in the surrounding metanephric mesenchyme (Karner et al. 2011, Yu et al. 2012, Ramalingam et al. 2018). Wnt4 promotes epithelialization of pre-tubular aggregates of metanephric mesenchyme, resulting in the formation of renal vesicles. Wnt9b also induces proliferation of a subset of metanephric mesenchyme to maintain a pool of nephron progenitors.
Literature References
PubMed ID Title Journal Year
21350016 Canonical Wnt9b signaling balances progenitor cell expansion and differentiation during kidney development

Karner, CM, Das, A, Ma, Z, Self, M, Chen, C, Lum, L, Oliver, G, Carroll, TJ

Development 2011
29705331 Disparate levels of beta-catenin activity determine nephron progenitor cell fate

Ramalingam, H, Fessler, AR, Das, A, Valerius, MT, Basta, J, Robbins, L, Brown, AC, Oxburgh, L, McMahon, AP, Rauchman, M, Carroll, TJ

Dev Biol 2018
22510988 Identification of molecular compartments and genetic circuitry in the developing mammalian kidney

Yu, J, Valerius, MT, Duah, M, Staser, K, Hansard, JK, Guo, JJ, McMahon, J, Vaughan, J, Faria, D, Georgas, K, Rumballe, B, Ren, Q, Krautzberger, AM, Junker, JP, Thiagarajan, RD, Machanick, P, Gray, PA, van Oudenaarden, A, Rowitch, DH, Stiles, CD, Ma, Q, Grimmond, SM, Bailey, TL, Little, MH, McMahon, AP

Development 2012
Participants
Input
Output
This event is regulated
Positively by
Regulator
N4GlycoAsn-PalmS Wnt9b [extracellular region] (Mus musculus)
Orthologous Events
Expression of WNT4 during nephron development (Homo sapiens)
Authored
May, B  (2023-03-29)
Created
May, B  (2023-03-30)
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