Expression of WNT4 during nephron development

Stable Identifier
R-HSA-9832331
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
ReviewStatus
3/5
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WNT9B secreted from the ureteric bud induces expression of WNT4 in the surrounding metanephric mesenchyme (inferred from mouse homologs). WNT4 promotes epithelialization of pre-tubular aggregates of metanephric mesenchyme, resulting in the formation of renal vesicles. WNT9B also induces proliferation of a subset of metanephric mesenchyme to maintain a pool of nephron progenitors.
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