Expression of Pou3f3 during nephron development

Stable Identifier
R-MMU-9832229
Type
Reaction [omitted]
Species
Mus musculus
Compartment
nucleoplasm
ReviewStatus
3/5
General
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PNG
Low
Medium
High
 | PPTX  | SBGN
Expression of Pou3f3 during nephron development
Pou3f3 (also called Brn1) is expressed in distal regions of renal vesicles, S-shaped bodies, and regions of the nephron that develop into the thick ascending limb and the macula densa of the loop of Henle and the distal tubule (Nakai et al. 2003, Yu et al. 2012, Kumar et al. 2016, Rieger et al. 2016). Lhx1 activates expression of Pou3f3 in developing nephrons (Kobayashi et al. 2005). Hnf1b activates expression of Pou3f3 in s-shaped bodies of developing nephrons (Massa et al. 2013). Missense mutations in Pou3f3 alters numbers and development of nephrons (Rieger et al. 2016) and cause kidney dysfunction (Kumar et al. 2016).
Literature References
PubMed ID Title Journal Year
27003440 Generation and Standardized, Systemic Phenotypic Analysis of Pou3f3L423P Mutant Mice

Kumar, S, Rathkolb, B, Kemter, E, Sabrautzki, S, Michel, D, Adler, T, Becker, L, Beckers, J, Busch, DH, Garrett, L, Hans, W, Hölter, SM, Horsch, M, Klingenspor, M, Klopstock, T, Racz, I, Rozman, J, Vargas Panesso, IL, Vernaleken, A, Zimmer, A, Fuchs, H, Gailus-Durner, V, Hrabě De Angelis, M, Wolf, E, Aigner, B

PLoS One 2016
27420727 Missense Mutation of POU Domain Class 3 Transcription Factor 3 in Pou3f3L423P Mice Causes Reduced Nephron Number and Impaired Development of the Thick Ascending Limb of the Loop of Henle

Rieger, A, Kemter, E, Kumar, S, Popper, B, Aigner, B, Wolf, E, Wanke, R, Blutke, A

PLoS One 2016
15930111 Distinct and sequential tissue-specific activities of the LIM-class homeobox gene Lim1 for tubular morphogenesis during kidney development

Kobayashi, A, Kwan, KM, Carroll, TJ, McMahon, AP, Mendelsohn, CL, Behringer, RR

Development 2005
12925600 Crucial roles of Brn1 in distal tubule formation and function in mouse kidney

Nakai, S, Sugitani, Y, Sato, H, Ito, S, Miura, Y, Ogawa, M, Nishi, M, Jishage, K, Minowa, O, Noda, T

Development 2003
22510988 Identification of molecular compartments and genetic circuitry in the developing mammalian kidney

Yu, J, Valerius, MT, Duah, M, Staser, K, Hansard, JK, Guo, JJ, McMahon, J, Vaughan, J, Faria, D, Georgas, K, Rumballe, B, Ren, Q, Krautzberger, AM, Junker, JP, Thiagarajan, RD, Machanick, P, Gray, PA, van Oudenaarden, A, Rowitch, DH, Stiles, CD, Ma, Q, Grimmond, SM, Bailey, TL, Little, MH, McMahon, AP

Development 2012
23362349 Hepatocyte nuclear factor 1β controls nephron tubular development

Massa, F, Garbay, S, Bouvier, R, Sugitani, Y, Noda, T, Gubler, MC, Heidet, L, Pontoglio, M, Fischer, E

Development 2013
Participants
Input
Output
This event is regulated
Positively by
Regulator
Lhx1 [nucleoplasm] (Mus musculus)
Regulator
Hnf1b [nucleoplasm] (Mus musculus)
Orthologous Events
Expression of POU3F3 during nephron development (Homo sapiens)
Authored
May, B  (2023-03-29)
Created
May, B  (2023-03-29)
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