Hnf1b binds the Irx2 gene

Stable Identifier
R-MMU-9832124
Type
Reaction [binding]
Species
Mus musculus
Compartment
nucleoplasm
ReviewStatus
3/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Hnf1b binds the Irx2 gene
Hnf1b binds several conserved sites between the Irx1 and Irx2 genes and activates expression of Irx2 in the intermediate region of the S-shaped body (Heliot et al. 2013). Chromatin in the intergenic region appears to form a loop that brings Hnf1b to within 587 bp of the Irx2 transcription start site (Heliot et al. 2013).
Literature References
PubMed ID Title Journal Year
23362348 HNF1B controls proximal-intermediate nephron segment identity in vertebrates by regulating Notch signalling components and Irx1/2

Heliot, C, Desgrange, A, Buisson, I, Prunskaite-Hyyryläinen, R, Shan, J, Vainio, S, Umbhauer, M, Cereghini, S

Development 2013
Participants
Input
Output
Orthologous Events
HNF1B binds the IRX2 gene (Homo sapiens)
Authored
May, B  (2023-03-28)
Created
May, B  (2023-03-28)
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