Expression of Six2 in metanephric mesenchyme

Stable Identifier
R-MMU-9831052
Type
Reaction [omitted]
Species
Mus musculus
Compartment
nucleoplasm
ReviewStatus
3/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Expression of Six2 in metanephric mesenchyme
Sine oculis homolog 2 (Six2) is expressed in metanephric mesenchyme during formation of the metanephros, the adult kidney (Wellik et al. 2002, Xu et al. 2003, Self et al. 2006, Gong et al. 2007). Six2 appears to maintain metanephric mesenchyme in a less differentiated, more proliferative state (Self et al. 2006, Kobayashi et al. 2008, Park et al. 2012).
Literature References
PubMed ID Title Journal Year
17785448 A Hox-Eya-Pax complex regulates early kidney developmental gene expression

Gong, KQ, Yallowitz, AR, Sun, H, Dressler, GR, Wellik, DM

Mol Cell Biol 2007
17036046 Six2 is required for suppression of nephrogenesis and progenitor renewal in the developing kidney

Self, M, Lagutin, OV, Bowling, B, Hendrix, J, Cai, Y, Dressler, GR, Oliver, G

EMBO J 2006
12783782 Six1 is required for the early organogenesis of mammalian kidney

Xu, PX, Zheng, W, Huang, L, Maire, P, Laclef, C, Silvius, D

Development 2003
12050119 Hox11 paralogous genes are essential for metanephric kidney induction

Wellik, DM, Hawkes, PJ, Capecchi, MR

Genes Dev 2002
Participants
Input
Output
This event is regulated
Positively by
Regulator
Eya1:Pax2:Hox11 paralog:Six2 gene [nucleoplasm] (Mus musculus)
Active Unit
Eya1 [nucleoplasm]
Pax2 [nucleoplasm]
Hox11 paralog [nucleoplasm]
Regulator
Six1 [nucleoplasm] (Mus musculus)
Orthologous Events
Expression of SIX2 in metanephric mesenchyme (Homo sapiens)
Authored
May, B  (2023-03-17)
Created
May, B  (2023-03-17)
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