Expression of SIX2 in metanephric mesenchyme

Stable Identifier
R-HSA-9831006
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
3/5
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Expression of SIX2 in metanephric mesenchyme
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Sine oculis homolog 2 (SIX2) is expressed in metanephric mesenchyme during formation of the metanephros, the adult kidney (O'Brien et al. 2016, and inferred from mouse homologs). Expression continues into development of nephrons where it is regulated by either SIX1 or SIX2 (O'Brien et al. 2016). In mouse embryos, Six2 appears to maintain metanephric mesenchyme in a less differentiated, more proliferative state (Self et al. 2006, Kobayashi et al. 2008, Park et al. 2012).
Participants
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Output
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as an event of
This event is regulated
Positively by
Regulator
EYA1:PAX2:HOX11 paralog:SIX2 gene [nucleoplasm] (Homo sapiens)
Active Unit
EYA1 [nucleoplasm]
HOX11 paralog [nucleoplasm]
PAX2 [nucleoplasm]
Regulator
SIX1 [nucleoplasm] (Homo sapiens)
Inferred From
Expression of Six2 in metanephric mesenchyme (Mus musculus)
Authored
May, B  (2023-03-17)
Created
May, B  (2023-03-17)
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