Expression of Epha4 in presomitic mesoderm

Stable Identifier
R-MMU-9825607
Type
Reaction [omitted]
Species
Mus musculus
Compartment
nucleoplasm, plasma membrane
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Expression of Epha4 in presomitic mesoderm
Epha4 is expressed in the rostral halves of somites (Nieto et al. 1992, Nomura-Kitabayashi et al. 2002) where it appears to play a role in the determination of somite boundaries through interaction with an Ephrin on an adjacent cell (inferred from zebrafish embryos in Durbin et al. 1998, Barrios et al. 2003 and from chicken embryos in Glazier et al. 2008). Expression of Epha4 is directly activated by Mesp2, which shows the same expression pattern (Nakajima et al. 2006).
Literature References
PubMed ID Title Journal Year
1295734 A receptor protein tyrosine kinase implicated in the segmental patterning of the hindbrain and mesoderm

Nieto, MA, Gilardi-Hebenstreit, P, Charnay, P, Wilkinson, DG

Development 1992
16728472 Identification of Epha4 enhancer required for segmental expression and the regulation by Mesp2

Nakajima, Y, Morimoto, M, Takahashi, Y, Koseki, H, Saga, Y

Development 2006
11973278 Hypomorphic Mesp allele distinguishes establishment of rostrocaudal polarity and segment border formation in somitogenesis

Nomura-Kitabayashi, A, Takahashi, Y, Kitajima, S, Inoue, T, Takeda, H, Saga, Y

Development 2002
Participants
Input
Output
This event is regulated
Positively by
Regulator
Mesp2:Epha4 gene [nucleoplasm] (Mus musculus)
Active Unit
Mesp2 [nucleoplasm]
Orthologous Events
Expression of EPHA4 in presomitic mesoderm (Homo sapiens)
Authored
May, B  (2023-01-25)
Reviewed
Chalamalasetty, RB  (2023-05-09)
Yamaguchi, TP  (2023-05-09)
Created
May, B  (2023-01-26)
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