Expression of Foxa2 in the definitive endoderm

Stable Identifier
R-MMU-9825053
Type
Reaction [omitted]
Species
Mus musculus
Compartment
nucleoplasm
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Expression of Foxa2 in the definitive endoderm
Foxa2 is expressed at the anterior end of the primitive steak in the progenitors of endoderm and axial mesoderm (Ang and Rossant 1994, Burtscher and Lickert 2009, reviewed in Bardot and Hadjantonakis 2020). Tbxt (T, Brachyury) directly activates transcription of Foxa2 (Lolas et al. 2014).
Literature References
PubMed ID Title Journal Year
19234065 Foxa2 regulates polarity and epithelialization in the endoderm germ layer of the mouse embryo

Burtscher, I, Lickert, H

Development 2009
8069909 HNF-3 beta is essential for node and notochord formation in mouse development

Ang, SL, Rossant, J

Cell 1994
24616493 Charting Brachyury-mediated developmental pathways during early mouse embryogenesis

Lolas, M, Valenzuela, PD, Tjian, R, Liu, Z

Proc Natl Acad Sci U S A 2014
25419850 SOX17 links gut endoderm morphogenesis and germ layer segregation

Viotti, M, Nowotschin, S, Hadjantonakis, AK

Nat Cell Biol 2014
Participants
Input
Output
This event is regulated
Positively by
Regulator
Tbxt:Foxa2 gene [nucleoplasm] (Mus musculus)
Active Unit
Tbxt [nucleoplasm]
Orthologous Events
Expression of FOXA2 in definitive endoderm (Homo sapiens)
Authored
May, B  (2023-01-20)
Reviewed
Salehin, N  (2023-02-28)
Tam, PPL  (2023-02-28)
Created
May, B  (2023-01-23)
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