Reactome | Expression of Sox17 in definitive endoderm

Expression of Sox17 in definitive endoderm

Stable Identifier

R-MMU-9823745

Type

Reaction [omitted]

Species

Mus musculus

Compartment

nucleoplasm

ReviewStatus

5/5

General

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SVG | | PPTX | SBGN

Expression of Sox17 in definitive endoderm

Sox17 is first expressed in the visceral endoderm, then in presumptive definitive endoderm before and during intercalation with visceral endoderm (Viotti et al. 2014). Wnt signaling activates Sox17 expression through the binding of Lef1:Ctnnb1 to the Sox17 promoter (Engert et al. 2013). Foxa2 and Gata4 also directly activate Sox17 by binding a distal enhancer (Trinh et al. 2022). Mixl1 also has role in activating Sox17 and other endodermally expressed genes (Mohn et al. 2003, Izumi et al. 2007, Lim et al. 2009). Loss of Mixl1 results in reduced recruitment of definitive endoderm and defective migration of endoderm during gastrulation (Hart et al. 2002).

Literature References

PubMed ID	Title	Journal	Year
36046192	Differential regulation of alternate promoter regions in Sox17 during endodermal and vascular endothelial development Wright, CVE, Wong, J, Sampson, L, Osipovich, AB, Magnuson, MA, Trinh, LT	iScience	2022
19038793	Enforced expression of Mixl1 during mouse ES cell differentiation suppresses hematopoietic mesoderm and promotes endoderm formation Wong, MS, Trounson, A, Lim, SM, Stanley, EG, Van Vranken, BE, Elefanty, AG, Hirst, CE, Pick, M, Pereira, L	Stem Cells	2009
23824574	Wnt/β-catenin signalling regulates Sox17 expression and is essential for organizer and endoderm formation in the mouse Dulev, S, Burtscher, I, Lickert, H, Engert, S, Liao, WP, Schotta, G	Development	2013
24616493	Charting Brachyury-mediated developmental pathways during early mouse embryogenesis Lolas, M, Valenzuela, PD, Tjian, R, Liu, Z	Proc Natl Acad Sci U S A	2014
17446562	Dissecting the molecular hierarchy for mesendoderm differentiation through a combination of embryonic stem cell culture and RNA interference Akimaru, H, Izumi, N, Nishikawa, S, Yasunaga, M, Era, T	Stem Cells	2007
25419850	SOX17 links gut endoderm morphogenesis and germ layer segregation Nowotschin, S, Hadjantonakis, AK, Viotti, M	Nat Cell Biol	2014
12117810	Mixl1 is required for axial mesendoderm morphogenesis and patterning in the murine embryo Hart, AH, Stadler, ES, Li, R, Stanley, EG, Robb, L, Elefanty, AG, Sourris, K, Tam, PPL, Hartley, L	Development	2002
12619131	Mouse Mix gene is activated early during differentiation of ES and F9 stem cells and induces endoderm in frog embryos Sahr, K, Mohn, D, Gudas, LJ, Weinstein, DC, Baron, MH, Zahradka, E, Zaret, KS, Dias, DC, Chen, SW, Keller, G, Ducker, CE, Dyer, MA	Dev Dyn	2003