Reactome | Expression of SOX17 in definitive endoderm

Expression of SOX17 in definitive endoderm

Stable Identifier

R-HSA-9823729

Type

Reaction [uncertain]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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Expression of SOX17 in definitive endoderm

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In mouse embryos, Sox17 is first expressed in the visceral endoderm, then in presumptive definitive endoderm before and during intercalation with visceral endoderm (Viotti et al. 2014). Expression of SOX17 is activated by WNT signaling via LEF1:CTNNB1 binding the SOX17 promoter (inferred from mouse homologs). During differentiation of human pluripotent stem cells to endoderm, expression of SOX17 is activated by NODAL signaling via phosphorylated SMAD2 and SMAD3 (Brown et al. 2011, Teo et al. 2011). GATA6, EOMES (Chia et al. 2019), BMP signaling (Xu et al. 2011), and MIXL1 (inferred from mouse homologs) also regulate SOX17.

Literature References

PubMed ID	Title	Journal	Year
21630377	Activin/Nodal signaling controls divergent transcriptional networks in human embryonic stem cells and in endoderm progenitors Brown, S, Teo, A, Pauklin, S, Hannan, N, Cho, CH, Lim, B, Vardy, L, Dunn, NR, Trotter, M, Pedersen, R, Vallier, L	Stem Cells	2011
21855631	Activin, BMP and FGF pathways cooperate to promote endoderm and pancreatic lineage cell differentiation from human embryonic stem cells Xu, X, Browning, VL, Odorico, JS	Mech Dev	2011
21245162	Pluripotency factors regulate definitive endoderm specification through eomesodermin Teo, AK, Arnold, SJ, Trotter, MW, Brown, S, Ang, LT, Chng, Z, Robertson, EJ, Dunn, NR, Vallier, L	Genes Dev.	2011