Kdm5a demethylates histone H3 trimethyllysine-4 (H3K4me3)

Stable Identifier
R-MMU-9822463
Type
Reaction [transition]
Species
Mus musculus
Compartment
nucleoplasm
ReviewStatus
5/5
General
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Kdm5a demethylates histone H3 trimethyllysine-4 (H3K4me3)
The histone demethylase Kdm5a (Jarid1a, Rbbp2, Rbp2) demethylates trimethylated histone 3 lysine-4 (H3K4me3, lysine-5 of the preprotein) and can processively remove all three methyl groups to yield unmethylated H3K4 (inferred from the human homolog). Nucleosomes of oocytes and zygotes contain a high level of histone H3.3; nucleosomes of 2-cell embryos and later embryos contain a canonical distrubution of H3.1, H3.2, and H3.3 (Ishiuchi et al. 2021). At the 2-cell stage, Kdm5a and Kdm5b are responsible for demethylating the broad, gene-spanning regions of H3K4me3 that are inherited from oocytes (Dahl et al. 2016). The result is peaks of H3K4me3 at the 5' and 3' ends of genes.
Literature References
PubMed ID Title Journal Year
27626377 Broad histone H3K4me3 domains in mouse oocytes modulate maternal-to-zygotic transition

Dahl, JA, Jung, I, Aanes, H, Greggains, GD, Manaf, A, Lerdrup, M, Li, G, Kuan, S, Li, B, Lee, AY, Preissl, S, Jermstad, I, Haugen, MH, Suganthan, R, Bjørås, M, Hansen, K, Dalen, KT, Fedorcsak, P, Ren, B, Klungland, A

Nature 2016
Participants
Input
Output
Catalyst Activity

histone H3K4 demethylase activity of Kdm5a:Fe2+ [nucleoplasm]

Physical Entity
Kdm5a:Fe2+ [nucleoplasm] (Mus musculus)
Activity
histone H3K4 demethylase activity (GO:0032453)
Orthologous Events
KDM5A demethylates histone H3 trimethyllysine-4 (H3K4me3) (Homo sapiens)
Authored
May, B  (2022-12-24)
Reviewed
Xie, W  (2023-08-08)
Created
May, B  (2022-12-24)
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