Dis3l2 hydrolyzes uridylated mRNA

Stable Identifier
R-MMU-9822432
Type
Reaction [omitted]
Species
Mus musculus
Compartment
cytosol
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Dis3l2 hydrolyzes uridylated mRNA
Pabpn1 bound to 3' uridylated mRNA recruits Dis3l2, an exosome-independent 3'-5' exoribonuclease that degrades the mRNA (Zhao et al. 2022).
Literature References
PubMed ID Title Journal Year
34904664 Nuclear poly(A) binding protein 1 (PABPN1) mediates zygotic genome activation-dependent maternal mRNA clearance during mouse early embryonic development

Zhao, LW, Fan, HY, Zhu, YZ, Shen, L, Pi, SB, Wu, YW

Nucleic Acids Res 2022
Participants
Input
Output
Catalyst Activity

3'-5'-RNA exonuclease activity of Dis3l2:Pabpn1:uridylated partially deadenylated mRNA complex [cytosol]

Physical Entity
Dis3l2:Pabpn1:uridylated partially deadenylated mRNA complex [cytosol] (Mus musculus)
Activity
3'-5'-RNA exonuclease activity (GO:0000175)
Orthologous Events
DIS3L2 hydrolyzes uridylated mRNA (Homo sapiens)
Authored
May, B  (2022-12-23)
Reviewed
Xie, W  (2023-08-08)
Created
May, B  (2022-12-23)
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