CCR4-NOT deadenylates mRNA in CCR4-NOT:Btg4:Pabpn1l:mRNP

Stable Identifier
R-MMU-9822325
Type
Reaction [transition]
Species
Mus musculus
Compartment
cytosol
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
CCR4-NOT deadenylates mRNA in CCR4-NOT:Btg4:Pabpn1l:mRNP
Btg4 bound to Pabpn1l and eIF4E of the mRNP recruits the CCR4-NOT complex via an interaction between Btg4 and Cnot7 of the CCR4-NOT complex (Yu et al. 2016, Liu et al. 2016, Pasternak et al. 2016, Zhao et al. 2020). Cnot7 then deadenylates the mRNA, targeting the mRNA for degradation (Yu et al. 2016, Liu et al. 2016, Pasternak et al. 2016, Zhao et al. 2020).
Literature References
PubMed ID Title Journal Year
27190313 BTG4 is a key regulator for maternal mRNA clearance during mouse early embryogenesis

Liu, Y, Lu, X, Shi, J, Yu, X, Zhang, X, Zhu, K, Yi, Z, Duan, E, Li, L

J Mol Cell Biol 2016
27605379 The BTG4 and CAF1 complex prevents the spontaneous activation of eggs by deadenylating maternal mRNAs

Pasternak, M, Pfender, S, Santhanam, B, Schuh, M

Open Biol 2016
32558204 PABPN1L mediates cytoplasmic mRNA decay as a placeholder during the maternal-to-zygotic transition

Zhao, LW, Zhu, YZ, Chen, H, Wu, YW, Pi, SB, Chen, L, Shen, L, Fan, HY

EMBO Rep 2020
27065194 BTG4 is a meiotic cell cycle-coupled maternal-zygotic-transition licensing factor in oocytes

Yu, C, Ji, SY, Sha, QQ, Dang, Y, Zhou, JJ, Zhang, YL, Liu, Y, Wang, ZW, Hu, B, Sun, QY, Sun, SC, Tang, F, Fan, HY

Nat Struct Mol Biol 2016
Participants
Input
Output
Catalyst Activity

poly(A)-specific ribonuclease activity of CCR4-NOT:Btg4:Pabpn1l:mRNP [cytosol]

Physical Entity
CCR4-NOT:Btg4:Pabpn1l:mRNP [cytosol] (Mus musculus)
Activity
poly(A)-specific ribonuclease activity (GO:0004535)
Orthologous Events
CCR4-NOT deadenylates mRNA in CCR4-NOT:BTG4:PABPN1L:mRNP (Homo sapiens)
Authored
May, B  (2022-12-22)
Reviewed
Xie, W  (2023-08-08)
Created
May, B  (2022-12-23)
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