CCR4-NOT deadenylates mRNA in CCR4-NOT:BTG4:PABPN1L:mRNP

Stable Identifier
R-HSA-9822311
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
CCR4-NOT deadenylates mRNA in CCR4-NOT:BTG4:PABPN1L:mRNP
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
BTG4 bound to PABPN1L and eIF4E of the mRNP recruits the CCR4-NOT complex via an interaction between BTG4 and CNOT7 of the CCR4-NOT complex (inferred from mouse homologs). CNOT7 then deadenylates the mRNA, targeting the mRNA for degradation (inferred from mouse homologs).
Participants
Input
Output
Participates
as an event of
Catalyst Activity

poly(A)-specific ribonuclease activity of CCR4-NOT:BTG4:PABPN1L:mRNP [cytosol]

Physical Entity
CCR4-NOT:BTG4:PABPN1L:mRNP [cytosol] (Homo sapiens)
Activity
poly(A)-specific ribonuclease activity (GO:0004535)
Inferred From
CCR4-NOT deadenylates mRNA in CCR4-NOT:Btg4:Pabpn1l:mRNP (Mus musculus)
Authored
May, B  (2022-12-22)
Reviewed
Xie, W  (2023-08-08)
Created
May, B  (2022-12-23)
Cite Us!