Reactome | Slc22a8 transports Cipro into renal cell

Slc22a8 transports Cipro into renal cell

Stable Identifier

R-MMU-9794643

Type

Reaction [transition]

Species

Mus musculus

Compartment

extracellular region, basolateral plasma membrane, cytosol

ReviewStatus

5/5

General

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SVG | | PPTX | SBGN

Slc22a8 transports Cipro into renal cell

Because of its high renal clearance, ciprofloxacin (Cipro) is probably not reabsorbed by renal tubular cells. In addition to glomerular secretion, Cipro is also secreted contraluminally by tubular cells (reviewed by Sörgel & Kinzig, 1993). The organic anion transporter Slc22a8 (mOAT3) is highly expressed in kidney (Kobayashi et al, 2004). Cipro interacts with Slc22a8 and inhibits Slc22a8-mediated transport of estrone-3-sulfate competitively (VanWert et al, 2008; reviewed in Burckhardt, 2012).

Literature References

PubMed ID	Title	Journal	Year
8383921	Pharmacokinetics of gyrase inhibitors, Part 2: Renal and hepatic elimination pathways and drug interactions Sörgel, F, Kinzig, M	Am J Med	1993
18381565	Organic anion transporter 3 (oat3/slc22a8) interacts with carboxyfluoroquinolones, and deletion increases systemic exposure to ciprofloxacin Vanwert, AL, Srimaroeng, C, Sweet, DH	Mol Pharmacol	2008
15100168	Renal transport of organic compounds mediated by mouse organic anion transporter 3 (mOat3): further substrate specificity of mOat3 Kobayashi, Y, Ohshiro, N, Tsuchiya, A, Kohyama, N, Ohbayashi, M, Yamamoto, T	Drug Metab Dispos	2004
22841915	Drug transport by Organic Anion Transporters (OATs) Burckhardt, G	Pharmacol Ther	2012