Reactome | SLC22A8 transports Cipro into renal cell

SLC22A8 transports Cipro into renal cell

Stable Identifier

R-HSA-9794830

Type

Reaction [transition]

Species

Homo sapiens

Compartment

extracellular region, basolateral plasma membrane, cytosol

ReviewStatus

5/5

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SLC22A8 transports Cipro into renal cell

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Because of its high renal clearance, ciprofloxacin (Cipro) is probably not reabsorbed by renal tubular cells. In addition to glomerular secretion, Cipro is also secreted contraluminally by tubular cells (reviewed by Sörgel & Kinzig, 1993). The organic anion transporter SLC22A8 (hOAT3) is highly expressed in kidney and brain (Motohashi et al, 2002). Cipro interacts with SLC22A8. In mice, it inhibits mOAT3-mediated transport of estrone-3-sulfate competitively (VanWert et al, 2008; reviewed in Burckhardt, 2012).

Literature References

PubMed ID	Title	Journal	Year
8383921	Pharmacokinetics of gyrase inhibitors, Part 2: Renal and hepatic elimination pathways and drug interactions Kinzig, M, Sörgel, F	Am J Med	1993
18381565	Organic anion transporter 3 (oat3/slc22a8) interacts with carboxyfluoroquinolones, and deletion increases systemic exposure to ciprofloxacin Vanwert, AL, Srimaroeng, C, Sweet, DH	Mol Pharmacol	2008
22841915	Drug transport by Organic Anion Transporters (OATs) Burckhardt, G	Pharmacol Ther	2012
11912245	Gene expression levels and immunolocalization of organic ion transporters in the human kidney Masuda, S, Motohashi, H, Goto, M, Fukatsu, A, Sakurai, Y, Urakami, Y, Inui, KI, Ogawa, O, Saito, H	J Am Soc Nephrol	2002