Dll3 binds Notch1

Stable Identifier
R-MMU-9793875
Type
Reaction [binding]
Species
Mus musculus
Compartment
endosome membrane
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Dll3 binds Notch1
Dll3 interacts with Notch1 when the two proteins are expressed in the same cell (Ladi et al. 2005). The interaction occurs in endosomes and targets Notch1 for degradation in lysosomes before Notch1 can be presented at the cell surface, resulting in an inhibition of signaling by Notch1 (Chapman et al. 2011).
Literature References
PubMed ID Title Journal Year
16144902 The divergent DSL ligand Dll3 does not activate Notch signaling but cell autonomously attenuates signaling induced by other DSL ligands

Nichols, JT, Miyamoto, A, Yao, C, Ge, W, Sun, YE, Weinmaster, G, Kintner, C, Yang, LT, Boulter, J, Ladi, E

J Cell Biol 2005
21147753 Notch inhibition by the ligand DELTA-LIKE 3 defines the mechanism of abnormal vertebral segmentation in spondylocostal dysostosis

Sparrow, DB, Chapman, G, Dunwoodie, SL, Kremmer, E

Hum Mol Genet 2011
Participants
Input
Output
Orthologous Events
DLL3 binds NOTCH1 (Homo sapiens)
Authored
May, B  (2022-06-19)
Reviewed
Chalamalasetty, RB  (2022-11-09)
Yamaguchi, TP  (2022-11-09)
Created
May, B  (2022-06-24)
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