DLL3 binds NOTCH1

Stable Identifier
R-HSA-9793852
Type
Reaction [binding]
Species
Homo sapiens
Compartment
endosome membrane
ReviewStatus
5/5
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DLL3 binds NOTCH1
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DLL3 interacts with NOTCH1 when the two proteins are expressed in the same cell (inferred from mouse homologs). The interaction occurs in endosomes and targets NOTCH1 for degradation in lysosomes before NOTCH1 can be presented at the cell surface, resulting in an inhibition of signaling by NOTCH1 (inferred from mouse homologs).
Participants
Input
Output
Participates
as an event of
Inferred From
Dll3 binds Notch1 (Mus musculus)
Authored
May, B  (2022-06-19)
Reviewed
Chalamalasetty, RB  (2022-11-09)
Yamaguchi, TP  (2022-11-09)
Created
May, B  (2022-06-24)
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