Npas4 binds Fos gene enhancer

Stable Identifier
R-MMU-9768954
Type
Reaction [binding]
Species
Mus musculus
Compartment
nucleoplasm
ReviewStatus
5/5
General
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Npas4 binds Fos gene enhancer
In mouse cortical and hippocampal neurons Npas4 binds an enhancer element of the Fos gene (Kim et al. 2010; Ramamoorthi et al. 2011). The heterodimers of Npas4 with Arnt, Arnt2 and Arntl are annotated as candidates for Fos gene binding.
Literature References
PubMed ID Title Journal Year
20393465 Widespread transcription at neuronal activity-regulated enhancers

Kim, TK, Hemberg, M, Gray, JM, Costa, AM, Bear, DM, Wu, J, Harmin, DA, Laptewicz, M, Barbara-Haley, K, Kuersten, S, Markenscoff-Papadimitriou, E, Kuhl, D, Bito, H, Worley, PF, Kreiman, G, Greenberg, ME

Nature 2010
22194569 Npas4 regulates a transcriptional program in CA3 required for contextual memory formation

Ramamoorthi, K, Fropf, R, Belfort, GM, Fitzmaurice, HL, McKinney, RM, Neve, RL, Otto, T, Lin, Y

Science 2011
Participants
Input
Output
Orthologous Events
NPAS4 binds FOS gene enhancer (Homo sapiens)
Authored
Orlic-Milacic, M  (2022-04-08)
Reviewed
Lin, Y  (2022-07-29)
Created
Orlic-Milacic, M  (2022-03-15)
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