Snai1 binds the Cdh1 (E-Cadherin) gene

Stable Identifier
R-MMU-9756411
Type
Reaction [binding]
Species
Mus musculus
Compartment
nucleoplasm
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Snai1 binds the Cdh1 (E-Cadherin) gene
Snail1 (Snai1) protein binds the promoter of the E-Cadherin (Cdh1) gene and represses expression of Cdh1 (Cano et al. 2000). Repression of Cdh1 by Snai1 results in a reduction in Cdh1 protein at the plasma membrane that causes loss of contact between epithelial cells during the epithelial to mesenchyme transition that is required for mesoderm formation (Carver et al. 2001).
Literature References
PubMed ID Title Journal Year
19597490 A SNAIL1-SMAD3/4 transcriptional repressor complex promotes TGF-beta mediated epithelial-mesenchymal transition

Vincent, T, Neve, EP, Johnson, JR, Kukalev, A, Rojo, F, Albanell, J, Pietras, K, Virtanen, I, Philipson, L, Leopold, PL, Crystal, RG, de Herreros, AG, Moustakas, A, Pettersson, RF, Fuxe, J

Nat Cell Biol 2009
10655586 The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression

Cano, A, Pérez-Moreno, MA, Rodrigo, I, Locascio, A, Blanco, MJ, del Barrio, MG, Portillo, F, Nieto, MA

Nat Cell Biol 2000
Participants
Input
Output
Orthologous Events
SNAI1 binds the CDH1 gene (Homo sapiens)
Authored
May, B  (2021-10-10)
Reviewed
Probst, S  (2022-07-18)
Zissel, L  (2022-07-18)
Created
May, B  (2021-10-14)
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