Expression of Hand2 in cardiogenesis

Stable Identifier
R-MMU-9735328
Type
Reaction [omitted]
Species
Mus musculus
Compartment
nucleoplasm
ReviewStatus
3/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Expression of Hand2 in cardiogenesis
The Hand2 (dHand) gene is transcribed to yield mRNA and the mRNA is translated to yield Hand2 protein. Expression of Hand2 is restricted to the right ventricle during cardiogenesis. Expression of Hand2 is directly activated by Gata4 (McFadden et al. 2000, Zeisberg et al. 2005), Gata6 (McFadden et al. 2000), and Isl1:Ldb1 (Caputo et al. 2015, Gao et al. 2019). Function of Hand2 is required in the second heart field for cardiogenesis (Tsuchihashi et al. 2011).
Literature References
PubMed ID Title Journal Year
15902305 Morphogenesis of the right ventricle requires myocardial expression of Gata4

Zeisberg, EM, Ma, Q, Juraszek, AL, Moses, K, Schwartz, RJ, Izumo, S, Pu, WT

J Clin Invest 2005
31024170 Pioneering function of Isl1 in the epigenetic control of cardiomyocyte cell fate

Gao, R, Liang, X, Cheedipudi, S, Cordero, J, Jiang, X, Zhang, Q, Caputo, L, Günther, S, Kuenne, C, Ren, Y, Bhattacharya, S, Yuan, X, Barreto, G, Chen, Y, Braun, T, Evans, SM, Sun, Y, Dobreva, G

Cell Res 2019
26321200 The Isl1/Ldb1 Complex Orchestrates Genome-wide Chromatin Organization to Instruct Differentiation of Multipotent Cardiac Progenitors

Caputo, L, Witzel, HR, Kolovos, P, Cheedipudi, S, Looso, M, Mylona, A, van IJcken, WF, Laugwitz, KL, Evans, SM, Braun, T, Soler, E, Grosveld, F, Dobreva, G

Cell Stem Cell 2015
11076755 A GATA-dependent right ventricular enhancer controls dHAND transcription in the developing heart

McFadden, DG, Charité, J, Richardson, JA, Srivastava, D, Firulli, AB, Olson, EN

Development 2000
Participants
Input
Output
This event is regulated
Positively by
Regulator
Gata4:Gata6:Isl1:Ldb1:Hand2 gene [nucleoplasm] (Mus musculus)
Orthologous Events
Expression of HAND2 in cardiogenesis (Homo sapiens)
Authored
May, B  (2021-06-23)
Created
May, B  (2021-06-24)
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