Expression of HAND2 in cardiogenesis

Stable Identifier
R-HSA-9735335
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
3/5
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Expression of HAND2 in cardiogenesis
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The HAND2 (dHAND) gene is transcribed to yield mRNA and the mRNA is translated to yield HAND2 protein. Expression of HAND2 is restricted to the right ventricle during cardiogenesis. Expression of HAND2 is directly activated by GATA4, GATA6 (Sharma et al. 2020), and ISL1:LDB1 (inferred from mouse homologs).
Literature References
PubMed ID Title Journal Year
33054971 GATA6 mutations in hiPSCs inform mechanisms for maldevelopment of the heart, pancreas, and diaphragm

Sharma, A, Wasson, LK, Willcox, JA, Morton, SU, Gorham, JM, DeLaughter, DM, Neyazi, M, Schmid, M, Agarwal, R, Jang, MY, Toepfer, CN, Ward, T, Kim, Y, Pereira, AC, DePalma, SR, Tai, A, Kim, S, Conner, D, Bernstein, D, Gelb, BD, Chung, WK, Goldmuntz, E, Porter, G, Tristani-Firouzi, M, Srivastava, D, Seidman, JG, Seidman, CE, Consortium, C

Elife 2020
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
SMYD1 [nucleoplasm] (Homo sapiens)
Regulator
GATA4:GATA6:ISL1:LDB1:HAND2 gene [nucleoplasm] (Homo sapiens)
Inferred From
Expression of Hand2 in cardiogenesis (Mus musculus)
Authored
May, B  (2021-06-23)
Created
May, B  (2021-06-24)
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