Expression of Isl1 in cardiogenesis

Stable Identifier
R-MMU-9735145
Type
Reaction [omitted]
Species
Mus musculus
Compartment
nucleoplasm
ReviewStatus
3/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Expression of Isl1 in cardiogenesis
The Isl1 gene is transcribed to yield mRNA and the mRNA is translated to yield Isl1 protein. Transcription of Isl1 is directly activated in the second heart field (SHF) (Cai et al. 2003) by Gata4 (Kappen and Salbaum et al. 2009) and Lef1:Ctnnb1 (beta-catenin) (Lin et al. 2007). Transcription of Isl1 is positively regulated, perhaps directly, by Tbx1 (Liao et al. 2008).
Literature References
PubMed ID Title Journal Year
17519333 Beta-catenin directly regulates Islet1 expression in cardiovascular progenitors and is required for multiple aspects of cardiogenesis

Lin, L, Cui, L, Zhou, W, Dufort, D, Zhang, X, Cai, CL, Bu, L, Yang, L, Martin, J, Kemler, R, Rosenfeld, MG, Chen, J, Evans, SM

Proc Natl Acad Sci U S A 2007
14667410 Isl1 identifies a cardiac progenitor population that proliferates prior to differentiation and contributes a majority of cells to the heart

Cai, CL, Liang, X, Shi, Y, Chu, PH, Pfaff, SL, Chen, J, Evans, S

Dev Cell 2003
18328475 Identification of downstream genetic pathways of Tbx1 in the second heart field

Liao, J, Aggarwal, VS, Nowotschin, S, Bondarev, A, Lipner, S, Morrow, BE

Dev Biol 2008
19598113 Identification of regulatory elements in the Isl1 gene locus

Kappen, C, Salbaum, JM

Int J Dev Biol 2009
Participants
Input
Output
This event is regulated
Positively by
Regulator
Gata4:Lef1:Ctnnb1:Isl1 gene [nucleoplasm] (Mus musculus)
Regulator
Tbx1 [nucleoplasm] (Mus musculus)
Orthologous Events
Expression of ISL1 in cardiogenesis (Homo sapiens)
Authored
May, B  (2021-06-18)
Created
May, B  (2021-06-21)
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