Expression of ISL1 in cardiogenesis

Stable Identifier
R-HSA-9735151
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
3/5
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Expression of ISL1 in cardiogenesis
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The ISL1 gene is transcribed to yield mRNA and the mRNA is translated to yield ISL1 protein. Transcription of ISL1 is directly activated in the second heart field (SHF) by GATA4 and LEF1:CTNNB1 (beta-catenin) (inferred from mouse homologs). Transcription of ISL1 is positively regulated, perhaps directly, by TBX1 (inferred from mouse homologs). In mice, Isl1-positive cells in the second heart field can generate endothelial, cardiac, and smooth muscle cells (Moretti et al. 2006)
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
TBX1 [nucleoplasm] (Homo sapiens)
Regulator
GATA4:LEF1:CTNNB1:ISL1 gene [nucleoplasm] (Homo sapiens)
Inferred From
Expression of Isl1 in cardiogenesis (Mus musculus)
Authored
May, B  (2021-06-18)
Created
May, B  (2021-06-21)
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