Trpm4 transports Na+ from the extracellular region to the cytosol

Stable Identifier
R-MMU-9717432
Type
Reaction [transition]
Species
Mus musculus
Compartment
plasma membrane
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Trpm4 transports Na+ from the extracellular region to the cytosol
Trpm4, a tetramer (Guo et al. 2017), is activated by calcium ions and passively transports monovalent cations across the plasma membrane resulting in depolarization of the cell (Demion et al. 2007, Dutta Banik et al. 2018). In mice, Trpm4 and Trpm5 are involved in sodium signals in type II taste cells and are required for perception of sweet, bitter, and umami tastes (Dutta Banik et al. 2018). Trpm4 is approximately 28-fold less sensitive to calcium than Trpm5 is (Ullrich et al. 2005).
Literature References
PubMed ID Title Journal Year
29311301 TRPM4 and TRPM5 are both required for normal signaling in taste receptor cells

Dutta Banik, D, Martin, LE, Freichel, M, Torregrossa, AM, Medler, KF

Proc Natl Acad Sci U S A 2018
29211714 Structures of the calcium-activated, non-selective cation channel TRPM4

Guo, J, She, J, Zeng, W, Chen, Q, Bai, XC, Jiang, Y

Nature 2017
17188667 TRPM4, a Ca2+-activated nonselective cation channel in mouse sino-atrial node cells

Demion, M, Bois, P, Launay, P, Guinamard, R

Cardiovasc Res 2007
15670874 Comparison of functional properties of the Ca2+-activated cation channels TRPM4 and TRPM5 from mice

Ullrich, ND, Voets, T, Prenen, J, Vennekens, R, Talavera, K, Droogmans, G, Nilius, B

Cell Calcium 2005
Participants
Input
Output
Catalyst Activity

calcium-activated cation channel activity of Trpm4 tetramer [plasma membrane]

Physical Entity
Trpm4 tetramer [plasma membrane] (Mus musculus)
Activity
calcium-activated cation channel activity (GO:0005227)
This event is regulated
Positively by
Regulator
Ca2+ [cytosol]
Orthologous Events
TRPM4 transports Na+ from the extracellular region to the cytosol (Homo sapiens)
Authored
May, B  (2021-03-10)
Reviewed
Jiang, P  (2021-08-08)
Created
May, B  (2021-03-10)
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