TRPM4 transports Na+ from the extracellular region to the cytosol

Stable Identifier
R-HSA-9717383
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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TRPM4 is activated by calcium ions and passively transports monovalent cations across the plasma membrane, resulting in depolarization of the cell (Launay et al. 2002, and inferred from mouse homologs). In mice, Trpm4 and Trpm5 are involved in sodium signals in type II taste cells and are required for perception of sweet, bitter, and umami tastes (Dutta Banik et al. 2018), however Ishimaru et al. (2006) reported that Trpm5, Pkd2l1, and Pkd1l3 but not other Trp channels were specifically and robustly expressed in mouse circumvallate taste cells.. TRPM4 is less sensitive to calcium than TRPM5 is (inferred from mouse homologs).

Literature References
PubMed ID Title Journal Year
12015988 TRPM4 is a Ca2+-activated nonselective cation channel mediating cell membrane depolarization

Launay, P, Fleig, A, Perraud, AL, Scharenberg, AM, Penner, R, Kinet, JP

Cell 2002
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Catalyst Activity

calcium activated cation channel activity of TRPM4 tetramer [plasma membrane]

This event is regulated
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