Ptk6 phosphorylates Stat3

Stable Identifier
R-MMU-9709373
Type
Reaction [transition]
Species
Mus musculus
Compartment
cytosol
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Ptk6 phosphorylates Stat3
In mouse, Ptk6-mediated phosphorylation of Stat3 is promoted by Stap2 and inhibited by Socs3. Heme oxygenase-1 (Hmox1) binds to tyrosine-705 and three domains on Stat3 (DNA-binding, linker, and transactivation domains), directly regulating Stat3 activation. Additionally it co-inhibits Socs3, a negative feedback factor of Stat3 activation, as well as RORγt, thereby decreasing Th2 and Th17 immune responses, and alleviating airway inflammation (Lin et al, 2020; Lin et al, 2017).
Literature References
PubMed ID Title Journal Year
32297710 Heme oxygenase-1 alleviates eosinophilic inflammation by inhibiting STAT3-SOCS3 signaling

Lin, X, Lv, J, Ge, D, Bai, H, Yang, Y, Wu, J

Pediatr Pulmonol 2020
28580587 Heme oxygenase-1 directly binds STAT3 to control the generation of pathogenic Th17 cells during neutrophilic airway inflammation

Lin, XL, Lv, JJ, Lv, J, Di, CX, Zhang, YJ, Zhou, T, Liu, JL, Xia, ZW

Allergy 2017
Participants
Input
Output
Catalyst Activity

protein tyrosine kinase activity of p-Y342-Ptk6:p-Y250-Stap2:Stat3 [cytosol]

Physical Entity
p-Y342-Ptk6:p-Y250-Stap2:Stat3 [cytosol] (Mus musculus)
Activity
protein tyrosine kinase activity (GO:0004713)
This event is regulated
Negatively by
Regulator
Hmox1 [cytosol] (Mus musculus)
Orthologous Events
PTK6 phosphorylates STAT3 (Homo sapiens)
Authored
Stephan, R  (2020-12-03)
Reviewed
Somers, J  (2021-01-23)
Created
Stephan, R  (2020-12-14)
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