PTK6 phosphorylates STAT3

Stable Identifier
R-HSA-9709918
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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PTK6 phosphorylates STAT3
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In humans, activated PTK6 (BRK) phosphorylates STAT3 on tyrosine residue Y705. PTK6-mediated phosphorylation of STAT3 is promoted by STAP2 and inhibited by SOCS3 (Liu et al. 2006, Ikeda et al. 2010).

In mouse, Ptk6-mediated phosphorylation of Stat3 is promoted by Stap2 and inhibited by Socs3. Heme oxygenase-1 (Hmox1) binds to tyrosine-705 and three domains on Stat3 (DNA-binding, linker, and transactivation domains), directly regulating Stat3 activation. Additionally it co-inhibits Socs3, a negative feedback factor of Stat3 activation, as well as RORγt, thereby decreasing Th2 and Th17 immune responses, and alleviating airway inflammation (Lin et al, 2020; Lin et al, 2017).
Literature References
PubMed ID Title Journal Year
16568091 Identification of STAT3 as a specific substrate of breast tumor kinase

Reich, NC, Gao, Y, Poli, V, Miller, WT, Liu, L, Qiu, H

Oncogene 2006
20929863 Interactions of STAP-2 with Brk and STAT3 participate in cell growth of human breast cancer cells

Miyasaka, Y, Matsuda, T, Mizushima, A, Nanbo, A, Ikeda, O, Sekine, Y, Nakasuji, M, Muromoto, R, Yamamoto, C, Yoshimura, A, Oritani, K

J. Biol. Chem. 2010
Participants
Input
Output
Participates
as an event of
Catalyst Activity

protein tyrosine kinase activity of p-Y342-PTK6:p-Y250-STAP2:STAT3 [cytosol]

Physical Entity
p-Y342-PTK6:p-Y250-STAP2:STAT3 [cytosol] (Homo sapiens)
Activity
protein tyrosine kinase activity (GO:0004713)
This event is regulated
Negatively by
Regulator
HMOX1 [cytosol] (Homo sapiens)
Inferred From
Ptk6 phosphorylates Stat3 (Mus musculus)
Authored
Stephan, R  (2020-12-14)
Reviewed
Somers, J  (2021-01-23)
Created
Stephan, R  (2020-12-18)
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