PTK6 phosphorylates STAT3

Stable Identifier
Reaction [transition]
Homo sapiens
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In humans, activated PTK6 (BRK) phosphorylates STAT3 on tyrosine residue Y705. PTK6-mediated phosphorylation of STAT3 is promoted by STAP2 and inhibited by SOCS3 (Liu et al. 2006, Ikeda et al. 2010).

In mouse, Ptk6-mediated phosphorylation of Stat3 is promoted by Stap2 and inhibited by Socs3. Heme oxygenase-1 (Hmox1) binds to tyrosine-705 and three domains on Stat3 (DNA-binding, linker, and transactivation domains), directly regulating Stat3 activation. Additionally it co-inhibits Socs3, a negative feedback factor of Stat3 activation, as well as RORγt, thereby decreasing Th2 and Th17 immune responses, and alleviating airway inflammation (Lin et al, 2020; Lin et al, 2017).

Literature References
PubMed ID Title Journal Year
16568091 Identification of STAT3 as a specific substrate of breast tumor kinase

Reich, NC, Gao, Y, Poli, V, Miller, WT, Liu, L, Qiu, H

Oncogene 2006
20929863 Interactions of STAP-2 with Brk and STAT3 participate in cell growth of human breast cancer cells

Miyasaka, Y, Matsuda, T, Mizushima, A, Nanbo, A, Ikeda, O, Sekine, Y, Nakasuji, M, Muromoto, R, Yamamoto, C, Yoshimura, A, Oritani, K

J. Biol. Chem. 2010
Catalyst Activity

protein tyrosine kinase activity of p-Y342-PTK6:p-Y250-STAP2:STAT3 [cytosol]

This event is regulated
Negatively by
Inferred From
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