Csf1r-associated PI3K phosphorylates phosphatidylinositol 4,5-bisphosphate

Stable Identifier
R-MMU-9682182
Type
Reaction [transition]
Species
Mus musculus
Compartment
plasma membrane
ReviewStatus
5/5
General
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Csf1r-associated PI3K phosphorylates phosphatidylinositol 4,5-bisphosphate
Phosphatidylinositol 3-kinase (PI3K) associated with the activated receptor for Csf1, Csf1r (M-CSFR), phosphorylates phosphatidylinositol 4,5-bisphosphate (PIP2) to yield phosphatidylinositol 3,4,5-trisphosphate (PIP3) (Reedijk et al. 1992, Lee and States 2000, Sampaio et al. 2011). The regulatory subunit of PI3K, PIK3R1, associates with phosphotyrosine-721 of Csf1r (Reedijk et al. 1992, Sampaio et al. 2011) and is important for proliferation, migration, and anti-inflammatory activity of macrophages (Munugalavadia et al. 2005, Sampaio et al. 2011, Yu et al. 2012, Caescu et al. 2015).
Literature References
PubMed ID Title Journal Year
22375015 Macrophage proliferation is regulated through CSF-1 receptor tyrosines 544, 559, and 807

Yu, W, Chen, J, Xiong, Y, Pixley, FJ, Yeung, YG, Stanley, ER

J. Biol. Chem. 2012
15769893 p85alpha subunit of class IA PI-3 kinase is crucial for macrophage growth and migration

Munugalavadla, V, Borneo, J, Ingram, DA, Kapur, R

Blood 2005
10958675 Both src-dependent and -independent mechanisms mediate phosphatidylinositol 3-kinase regulation of colony-stimulating factor 1-activated mitogen-activated protein kinases in myeloid progenitors

Lee, AW, States, DJ

Mol. Cell. Biol. 2000
1314163 Tyr721 regulates specific binding of the CSF-1 receptor kinase insert to PI 3'-kinase SH2 domains: a model for SH2-mediated receptor-target interactions

Reedijk, M, Liu, X, van der Geer, P, Letwin, K, Waterfield, MD, Hunter, T, Pawson, T

EMBO J. 1992
21610095 Phosphorylation of CSF-1R Y721 mediates its association with PI3K to regulate macrophage motility and enhancement of tumor cell invasion

Sampaio, NG, Yu, W, Cox, D, Wyckoff, J, Condeelis, J, Stanley, ER, Pixley, FJ

J. Cell. Sci. 2011
25573988 Colony stimulating factor-1 receptor signaling networks inhibit mouse macrophage inflammatory responses by induction of microRNA-21

Caescu, CI, Guo, X, Tesfa, L, Bhagat, TD, Verma, A, Zheng, D, Stanley, ER

Blood 2015
Participants
Input
Output
Catalyst Activity

1-phosphatidylinositol-3-kinase activity of Csf1 dimer:PolyUb,p-8Y-Csf1r dimer:Fyn,Hck,Src,Yes1:p-Y-Gab2:p-Y-Gab3:Grap2:Inpp5d:Inppl1:Pi3k:Ptpn11:p-Y-Shc1:p-Y-Plcg2 [plasma membrane]

Physical Entity
Csf1 dimer:PolyUb,p-8Y-Csf1r dimer:Fyn,Hck,Src,Yes1:p-Y-Gab2:p-Y-Gab3:Grap2:Inpp5d:Inppl1:Pi3k:Ptpn11:p-Y-Shc1:p-Y-Plcg2 [plasma membrane] (Mus musculus)
Activity
1-phosphatidylinositol-3-kinase activity (GO:0016303)
Orthologous Events
CSF1R-associated phosphatidylinositol 3-kinase (PI3K) phosphorylates PI(4,5)P2 (Homo sapiens)
Authored
May, B  (2020-04-04)
Reviewed
Stanley, ER  (2022-10-06)
Created
May, B  (2020-04-08)
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