Csf1r trans-autophosphorylates on multiple tyrosine residues

Stable Identifier
R-MMU-9680706
Type
Reaction [transition]
Species
Mus musculus
Compartment
plasma membrane
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Csf1r trans-autophosphorylates on multiple tyrosine residues
After Csf1r binds Csf1 and dimerizes, the Csf1r subunits of the dimer phosphorylate each other (transautophosphorylate) on 8 tyrosine residues (van der Geer et al. 1990, van der Geer and Hunter 1991, Baccarini et al. 1991, van der Geer and Hunter 1993, Myles et al. 1994, Wilhelmsen et al. 2002, Rohde et al. 2004, Takeshita et al. 2007, Wei et al. 2010, Sampaio et al. 2011). Tyrosine-599 in the juxtamembrane is phosphorylated first, relieving repression of kinase activity by tyrosine-599 (Yu et al. 2008, Xiong et al. 2011). Serine residues are also observed to be phosphorylated (Baccarini et al. 1991).
Literature References
PubMed ID Title Journal Year
8007983 Tyrosine 569 in the c-Fms juxtamembrane domain is essential for kinase activity and macrophage colony-stimulating factor-dependent internalization

Myles, GM, Brandt, CS, Carlberg, K, Rohrschneider, LR

Mol. Cell. Biol. 1994
15297464 A juxtamembrane tyrosine in the colony stimulating factor-1 receptor regulates ligand-induced Src association, receptor kinase function, and down-regulation

Rohde, CM, Schrum, J, Lee, AW

J. Biol. Chem. 2004
21041311 A CSF-1 receptor phosphotyrosine 559 signaling pathway regulates receptor ubiquitination and tyrosine phosphorylation

Xiong, Y, Song, D, Cai, Y, Yu, W, Yeung, YG, Stanley, ER

J. Biol. Chem. 2011
1652061 Tyrosine 706 and 807 phosphorylation site mutants in the murine colony-stimulating factor-1 receptor are unaffected in their ability to bind or phosphorylate phosphatidylinositol-3 kinase but show differential defects in their ability to induce early response gene transcription

van der Geer, P, Hunter, T

Mol. Cell. Biol. 1991
21610095 Phosphorylation of CSF-1R Y721 mediates its association with PI3K to regulate macrophage motility and enhancement of tumor cell invasion

Sampaio, NG, Yu, W, Cox, D, Wyckoff, J, Condeelis, J, Stanley, ER, Pixley, FJ

J. Cell. Sci. 2011
11850825 C-Cbl binds the CSF-1 receptor at tyrosine 973, a novel phosphorylation site in the receptor's carboxy-terminus

Wilhelmsen, K, Burkhalter, S, van der Geer, P

Oncogene 2002
8262059 Mutation of Tyr697, a GRB2-binding site, and Tyr721, a PI 3-kinase binding site, abrogates signal transduction by the murine CSF-1 receptor expressed in Rat-2 fibroblasts

van der Geer, P, Hunter, T

EMBO J. 1993
2160591 Identification of tyrosine 706 in the kinase insert as the major colony-stimulating factor 1 (CSF-1)-stimulated autophosphorylation site in the CSF-1 receptor in a murine macrophage cell line

van der Geer, P, Hunter, T

Mol. Cell. Biol. 1990
18519746 CSF-1 receptor structure/function in MacCsf1r-/- macrophages: regulation of proliferation, differentiation, and morphology

Yu, W, Chen, J, Xiong, Y, Pixley, FJ, Dai, XM, Yeung, YG, Stanley, ER

J. Leukoc. Biol. 2008
17420255 c-Fms tyrosine 559 is a major mediator of M-CSF-induced proliferation of primary macrophages

Takeshita, S, Faccio, R, Chappel, J, Zheng, L, Feng, X, Weber, JD, Teitelbaum, SL, Ross, FP

J. Biol. Chem. 2007
20504948 Functional overlap but differential expression of CSF-1 and IL-34 in their CSF-1 receptor-mediated regulation of myeloid cells

Wei, S, Nandi, S, Chitu, V, Yeung, YG, Yu, W, Huang, M, Williams, LT, Lin, H, Stanley, ER

J. Leukoc. Biol. 2010
1843210 Increased phosphorylation of the colony stimulating factor-1 receptor following transmembrane signaling

Baccarini, M, Li, W, Dello Sbarba, P, Stanley, ER

Receptor 1991
Participants
Input
Output
Catalyst Activity

protein tyrosine kinase activity of Csf1 dimer:Csf1r dimer [plasma membrane]

Physical Entity
Csf1 dimer:Csf1r dimer [plasma membrane] (Mus musculus)
Activity
protein tyrosine kinase activity (GO:0004713)
Orthologous Events
CSF1R trans-autophosphorylates on multiple tyrosine and serine residues (Homo sapiens)
Authored
May, B  (2020-03-28)
Reviewed
Stanley, ER  (2022-10-06)
Created
May, B  (2020-03-28)
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