Kcnip3 binds Npas4 gene promoter

Stable Identifier
R-MMU-9640074
Type
Reaction [binding]
Species
Mus musculus
Compartment
nucleoplasm
ReviewStatus
5/5
General
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PNG
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Medium
High
 | PPTX  | SBGN
Kcnip3 binds Npas4 gene promoter
In mouse neurons, in the absence of neuronal activity-induced calcium influx, Kcnip3 (DREAM) binds to the promoter of the Npas4 gene and represses Npas4 transcription (Mellström et al. 2014). Magnesium is required for stable binding of mouse Kcnip3 homotetramers to target DNA. Kcnip3 possesses one high-affinity, constitutive, Mg2+ binding site and two low-affinity Mg2+ sites (Osawa et al. 2005).
Literature References
PubMed ID Title Journal Year
24366545 DREAM controls the on/off switch of specific activity-dependent transcription pathways

Mellström, B, Sahún, I, Ruiz-Nuño, A, Murtra, P, Gomez-Villafuertes, R, Savignac, M, Oliveros, JC, Gonzalez, P, Kastanauskaite, A, Knafo, S, Zhuo, M, Higuera-Matas, A, Errington, ML, Maldonado, R, DeFelipe, J, Jefferys, JG, Bliss, TV, Dierssen, M, Naranjo, JR

Mol. Cell. Biol. 2014
Participants
Input
Output
This event is regulated
Negatively by
Regulator
Ca2+ [nucleoplasm]
Orthologous Events
KCNIP3 binds NPAS4 gene promoter (Homo sapiens)
Authored
Orlic-Milacic, M  (2022-04-08)
Reviewed
Lin, Y  (2022-07-29)
Created
Orlic-Milacic, M  (2019-03-20)
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