KCNIP3 binds NPAS4 gene promoter

Stable Identifier
R-HSA-9640060
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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KCNIP3 binds NPAS4 gene promoter
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Based on studies in mice, in the absence of neuronal activity-induced calcium influx, KCNIP3 (DREAM) binds to the promoter of the NPAS4 gene and represses NPAS4 transcription (Mellström et al. 2014). KCNIP3 binds to target promoters as a homotetramer (Carrion et al. 1999). Magnesium is required for stable binding of KCNIP3 homotetramers to target DNA. KCNIP3 possesses one high-affinity, constitutive, Mg2+ binding site and two low-affinity Mg2+ sites (Osawa et al. 2005).
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This event is regulated
Negatively by
Regulator
Ca2+ [nucleoplasm]
Inferred From
Kcnip3 binds Npas4 gene promoter (Mus musculus)
Authored
Orlic-Milacic, M  (2022-04-08)
Reviewed
Lin, Y  (2022-07-29)
Created
Orlic-Milacic, M  (2019-03-20)
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